Shz 1

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Cat.No. 4923 - Shz 1 | C13H11BrN2O3S | CAS No. 326886-05-9
Description: Activator of early cardiac genes in pluripotent stem cells; induces differentiation in M-PBMCs
Chemical Name: 2-[(5-Bromo-2-hydroxyphenyl)methylene]hydrazide benzenesulfonic acid
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity

Activator of early cardiac genes (including Nkx2.5) in pluripotent stem cells. Induces phenotypic differentiation in human mobilized peripheral blood mononuclear cells. Enhances myocardial regenerative repair by stem cells in a rat myocardial cryoinjury model.

Technical Data

M. Wt 355.21
Formula C13H11BrN2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 326886-05-9
PubChem ID 5334954
Smiles OC1=C(/C=N/NS(C2=CC=CC=C2)(=O)=O)C=C(Br)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.52 100
ethanol 17.76 50

Preparing Stock Solutions

The following data is based on the product molecular weight 355.21. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.08 mL 28.15 mL
5 mM 0.56 mL 2.82 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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References are publications that support the biological activity of the product.

Sadek et al (2008) Cardiogenic small molecules that enhance myocardial repair by stem cells. Proc.Natl.Acad.Sci.U.S.A. 105 6063 PMID: 18420817

If you know of a relevant reference for Shz 1, please let us know.

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Literature in this Area

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