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Description: Reagent for staining and detection of lipofuscin in senescent cells
Chemical Name: (2-Methyl-6-((E)-(4-((E)-phenyldiazenyl)naphthalen-1-yl)diazenyl)-2,3-dihydro-1H-perimidin-2-yl)methyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate
Purity: ≥95% (HPLC)
Literature (1)

Biological Activity for SenTraGor™

SenTraGor is a reagent for detecting lipofuscin in senescent cells. A highly lipophilic and biotinylated analog of Sudan Black B; can be detected using an anti-biotin antibody. Can be used in vivo and in vitro in any biological material including cell cultures, fresh and frozen tissues, and fixed embedded samples. Compatible with immunohistochemistry, flow cytometry and immunofluorescence analysis.

Licensing Information

Sold under license from University of Manchester Innovation Factory

Technical Data for SenTraGor™

M. Wt 698.85
Formula C39H38N8O3S
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 2171036-89-6
PubChem ID 166603878
Smiles [H][C@]12CS[C@H]([C@]1(NC(N2)=O)[H])CCCCC(OCC3(C)NC4=CC=CC5=C4C(N3)=CC=C5/N=N/C6=CC=C(C7=C6C=CC=C7)/N=N/C8=CC=CC=C8)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SenTraGor™

Solvent Max Conc. mg/mL Max Conc. mM
ethanol 6.99 10 with gentle warming
DMSO 13.98 20

Preparing Stock Solutions for SenTraGor™

The following data is based on the product molecular weight 698.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 7.15 mL 35.77 mL 71.55 mL
1 mM 1.43 mL 7.15 mL 14.31 mL
2 mM 0.72 mL 3.58 mL 7.15 mL
10 mM 0.14 mL 0.72 mL 1.43 mL

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References for SenTraGor™

References are publications that support the biological activity of the product.

Evangelou et al (2017) Robust, universal biomarker assay to detect senescent cells in biological specimens Aging Cell 16 192 PMID: 28165661

If you know of a relevant reference for SenTraGor™, please let us know.

View Related Products by Target

Keywords: SenTraGor™, SenTraGor™ supplier, sudan, black, B, lipofuscin, biotin, biotinylated, senescent, senescence, detection, detector, biomarker, GL13, Labels, and, Stains, 7555, Tocris Bioscience

Citations for SenTraGor™

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Literature in this Area

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Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals