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Cat.No. 2849 - SecinH3 | C24H20N4O4S | CAS No. 853625-60-2
Description: Sec7-specific GEF inhibitor (cytohesins)
Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Technical Data

M. Wt 460.5
Formula C24H20N4O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 853625-60-2
PubChem ID 1029232
Smiles O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.05 100
ethanol 4.61 10mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 460.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Hafner et al (2006) Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance. Nature 444 941 PMID: 17167487

Fuss et al (2006) The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444 945 PMID: 17167488

If you know of a relevant reference for SecinH3, please let us know.

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Keywords: SecinH3, supplier, Sec7-specific, GEF, inhibitors, inhibits, cytohesins, hCyh2, hCyh1, mCyh3, hCyh3, drosophila, steppke, G, Proteins, Small, G, Proteins, (Small), GTPase, G, Proteins, (Small), Tocris Bioscience

1 Citation for SecinH3

Citations are publications that use Tocris products. Selected citations for SecinH3 include:

Risse et al (2011) Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Pain 300 L958 PMID: 21460123

Do you know of a great paper that uses SecinH3 from Tocris? If so please let us know.

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