Pricing Availability   Qty
Description: Sec7-specific GEF inhibitor; selective for cytohesin family
Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide
Purity: ≥98% (HPLC)
Citations (4)

Biological Activity for SecinH3

SecinH3 is a Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Compound Libraries for SecinH3

SecinH3 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for SecinH3

M. Wt 460.5
Formula C24H20N4O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 853625-60-2
PubChem ID 1029232
Smiles O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SecinH3

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 46.05 100

Preparing Stock Solutions for SecinH3

The following data is based on the product molecular weight 460.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.17 mL 10.86 mL 21.72 mL
5 mM 0.43 mL 2.17 mL 4.34 mL
10 mM 0.22 mL 1.09 mL 2.17 mL
50 mM 0.04 mL 0.22 mL 0.43 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for SecinH3

Certificate of Analysis / Product Datasheet
Select another batch:

References for SecinH3

References are publications that support the biological activity of the product.

Hafner et al (2006) Inhibition of cytohesins by secinH3 leads to hepatic Ins resistance. Nature 444 941 PMID: 17167487

Fuss et al (2006) The cytohesin Steppke is essential for Ins signalling in Drosophila. Nature 444 945 PMID: 17167488

If you know of a relevant reference for SecinH3, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Arf GTPase Inhibitors

Keywords: SecinH3, SecinH3 supplier, Sec7-specific, GEF, inhibitors, inhibits, cytohesins, hCyh2, hCyh1, mCyh3, hCyh3, drosophila, steppke, G, Proteins, Small, Arf, 2849, Tocris Bioscience

4 Citations for SecinH3

Citations are publications that use Tocris products. Selected citations for SecinH3 include:

Ford et al (2018) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog 14 e1007051 PMID: 29727463

Guichard et al (2017) Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport. PLoS Pathog 13 e1006603 PMID: 28945820

Abdul-Salam et al (2019) CLIC4/Arf6 Pathway. Circ Res 124 52 PMID: 30582444

Risse et al (2011) Interleukin-13 inhibits proliferation and enhances contractility of human airway smooth muscle cells without change in contractile phenotype. Pain 300 L958 PMID: 21460123

Do you know of a great paper that uses SecinH3 from Tocris? Please let us know.

Reviews for SecinH3

There are currently no reviews for this product. Be the first to review SecinH3 and earn rewards!

Have you used SecinH3?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review