SANT-2

Pricing Availability Delivery Time Qty
Cat.No. 3617 - SANT-2 | C26H26ClN3O4 | CAS No. 329196-48-7
Description: Inhibitor of Hedgehog (Hh) signaling; antagonizes smoothened activity
Chemical Name: N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM). Displays allosteric binding characteristics similar to SANT-1 (Cat. No. 1974). Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively).

Compound Libraries

SANT-2 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 479.96
Formula C26H26ClN3O4
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 329196-48-7
PubChem ID 1367095
InChI Key VQOJFGFKIVFMDH-UHFFFAOYSA-N
Smiles ClC1=CC=C(NC(C4=CC(OCC)=C(OCC)C(OCC)=C4)=O)C=C1C3=NC2=CC=CC=C2N3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48 100
ethanol 48 100

Preparing Stock Solutions

The following data is based on the product molecular weight 479.96. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.08 mL 10.42 mL 20.84 mL
5 mM 0.42 mL 2.08 mL 4.17 mL
10 mM 0.21 mL 1.04 mL 2.08 mL
50 mM 0.04 mL 0.21 mL 0.42 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Rominger et al (2009) Evidence for allosteric interactions of antagonist binding to the smoothened receptor. J.Pharmacol.Exp.Ther. 329 995 PMID: 19304771

Chen et al (2002) Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci. 99 14071 PMID:


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Citations for SANT-2

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Literature in this Area

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Pathways for SANT-2

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