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Cat.No. 4989 - Salirasib | C22H30O2S | CAS No. 162520-00-5
Description: Ras inhibitor; also induces autophagy
Chemical Name: 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.

Technical Data

M. Wt 358.54
Formula C22H30O2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 162520-00-5
PubChem ID 5469318
Smiles C\C(CC/C=C(C)/CC/C=C(C)/C)=C/CSC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 35.85 100
1eq. NaOH 17.93 50

Preparing Stock Solutions

The following data is based on the product molecular weight 358.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.95 mL 27.89 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Schmukler et al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142 PMID: 23370967

Faigenbaum et al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316 PMID: 23530112

Haklai et al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306 PMID: 9477957

If you know of a relevant reference for Salirasib, please let us know.

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Keywords: Salirasib, Salirasib supplier, Ras, inhibitors, inhibits, induces, autophagy, GTPase, G, Proteins, (Small), Autophagy, 4989, Tocris Bioscience

1 Citation for Salirasib

Citations are publications that use Tocris products. Selected citations for Salirasib include:

Lee et al (2015) A systems-biological study on the identification of safe and effective molecular targets for the reduction of ultraviolet B-induced skin pigmentation. J Virol 5 10305 PMID: 25980672

Do you know of a great paper that uses Salirasib from Tocris? Please let us know.

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New Product Guide

New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

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