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5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol.
Racemate also available.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.03 mL||20.14 mL||40.27 mL|
|5 mM||0.81 mL||4.03 mL||8.05 mL|
|10 mM||0.4 mL||2.01 mL||4.03 mL|
|50 mM||0.08 mL||0.4 mL||0.81 mL|
References are publications that support the biological activity of the product.
Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386
Kalkman (1989) β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Eur.J.Pharmacol. 173 121 PMID: 2576226
Walter et al (1984) Stimulant and blocking effects of optical isomers of pin. on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 327 159 PMID: 6092972
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Keywords: (S)-(-)-Pindolol, (S)-(-)-Pindolol supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Adrenergic, Beta-3, 1060, Tocris Bioscience
1 Citation for (S)-(-)-Pindolol
Citations are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:
Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Neurosci 329 350 PMID: 19144685
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Literature in this Area
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.