(S)-(-)-Pindolol

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Cat.No. 1060 - (S)-(-)-Pindolol | C14H20N2O2 | CAS No. 26328-11-0
Description: β3 partial agonist. More active enantiomer of pindolol (Cat. No. 0994)
Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol (Cat. No. 0994).

Technical Data

M. Wt 248.32
Formula C14H20N2O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 26328-11-0
PubChem ID 688095
InChI Key JZQKKSLKJUAGIC-NSHDSACASA-N
Smiles CC(C)NC[C@H](O)COC1=C2C=CNC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in 1eq. HCl

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386

Kalkman (1989) β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Eur.J.Pharmacol. 173 121 PMID: 2576226

Walter et al (1984) Stimulant and blocking effects of optical isomers of pindolol on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 327 159 PMID: 6092972


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Keywords: (S)-(-)-Pindolol, supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Adrenergic, Beta-3, Receptors, Tocris Bioscience

1 Citation for (S)-(-)-Pindolol

Citations are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Neurosci 329 350 PMID: 19144685


Do you know of a great paper that uses (S)-(-)-Pindolol from Tocris? If so please let us know.

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Pathways for (S)-(-)-Pindolol

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