Discontinued Product

(S)-(-)-Pindolol (Cat. No. 1060) has been withdrawn from sale for commercial reasons.
Description: β3 partial agonist; also 5-HT1A and 5-HT1B antagonist; more active enantiomer of pindolol (Cat. No. 0994)
Chemical Name: (S)-1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99% (HPLC)
Citations (1)
Literature (1)

Biological Activity for (S)-(-)-Pindolol

(S)-(-)-Pindolol is a 5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors. More active enantiomer of pindolol.

Racemate also available.

Technical Data for (S)-(-)-Pindolol

M. Wt 248.32
Formula C14H20N2O2
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 26328-11-0
PubChem ID 688095
Smiles CC(C)NC[C@H](O)COC1=C2C=CNC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (S)-(-)-Pindolol

Certificate of Analysis / Product Datasheet
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References for (S)-(-)-Pindolol

References are publications that support the biological activity of the product.

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386

Kalkman (1989) β-Adrenoceptor blockade in rats enhances the ambulation induced by 5-HT1A receptor agonists. Eur.J.Pharmacol. 173 121 PMID: 2576226

Walter et al (1984) Stimulant and blocking effects of optical isomers of pin. on the sinoatrial node and trachea of guinea pig. Role of β-adrenoceptor subtypes in the dissociation between blockade and stimulation. Naunyn Schmiedebergs Arch.Pharmacol. 327 159 PMID: 6092972

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Keywords: (S)-(-)-Pindolol, (S)-(-)-Pindolol supplier, β3-adrenoceptor, b3-adrenoceptor, β3-adrenergic, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Adrenergic, Beta-3, 1060, Tocris Bioscience

1 Citation for (S)-(-)-Pindolol

Citations are publications that use Tocris products. Selected citations for (S)-(-)-Pindolol include:

Kaya et al (2009) Coupling of β2-adrenoceptors to XLαs and Gαs: a new insight into ligand-induced G protein activation. Front Neurosci 329 350 PMID: 19144685

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.