Pindolol

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Cat.No. 0994 - Pindolol | C14H20N2O2 | CAS No. 13523-86-9
Description: β3 partial agonist
Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature

Biological Activity

5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors.

S-enantiomer also available.

Technical Data

M. Wt 248.32
Formula C14H20N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 13523-86-9
PubChem ID 4828
InChI Key JZQKKSLKJUAGIC-UHFFFAOYSA-N
Smiles CC(C)NCC(O)COC1=C2C=CNC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 24.83 100

Preparing Stock Solutions

The following data is based on the product molecular weight 248.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.03 mL 20.14 mL 40.27 mL
5 mM 0.81 mL 4.03 mL 8.05 mL
10 mM 0.4 mL 2.01 mL 4.03 mL
50 mM 0.08 mL 0.4 mL 0.81 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Blin et al (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol.Pharmacol. 44 1094 PMID: 7903415

Clifford et al (1998) Electrophysiological and neurochemical evidence that pindolol has agonist properties at the 5-HT1A autoreceptor in vivo. Br.J.Pharmacol. 124 206 PMID: 9630361

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Merck Index 12 7597


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View all Adrenergic β3 Receptor Agonists

Keywords: Pindolol, Pindolol supplier, 5-HT1A/1B, antagonists, β3-adrenoceptor, β3-adrenergic, b3-adrenoceptor, b3-adrenergic, partial, agonists, Serotonin, 5-HT1A, Receptors, 5-HT1B, Adrenergic, Beta-3, 0994, Tocris Bioscience

5 Citations for Pindolol

Citations are publications that use Tocris products. Selected citations for Pindolol include:

Luo (2017) β2-adrenoreceptor Inverse Agonist Down-regulates Muscarine Cholinergic Subtype-3 Receptor and Its Downstream Signal Pathways in Airway Smooth Muscle Cells in vitro. Scientific Reports 7 39905 PMID: 28051147

Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739

Littmann et al (2015) Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands. Front Microbiol 355 183 PMID: 26306764

Zaytseva et al (2013) Resonant waveguide grating biosensor-enabled label-free and fluorescence detection of cell adhesion. Sens Actuators B Chem 188 PMID: 24319319

Marinelli et al (2004) Serotonergic and nonserotonergic dorsal raphe neurons are pharmacologically and electrophysiologically heterogeneous. J Neurophysiol 92 3532 PMID: 15254076


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Literature in this Area

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