Pindolol

Discontinued Product

Pindolol (Cat. No. 0994) has been withdrawn from sale for commercial reasons.
Cat.No. 0994 - Pindolol | C14H20N2O2 | CAS No. 13523-86-9
Description: β3 partial agonist; also a 5-HT1A and 5-HT1B antagonist
Chemical Name: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (4)

Biological Activity

5-HT1A/1B receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β3-adrenoceptors.

S-enantiomer also available.

Technical Data

M. Wt 248.32
Formula C14H20N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 13523-86-9
PubChem ID 4828
InChI Key JZQKKSLKJUAGIC-UHFFFAOYSA-N
Smiles CC(C)NCC(O)COC1=C2C=CNC2=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Blin et al (1993) Structural and conformational features determining selective signal transduction in the β3-adrenergic receptor. Mol.Pharmacol. 44 1094 PMID: 7903415

Clifford et al (1998) Electrophysiological and neurochemical evidence that pin. has agonist properties at the 5-HT1A autoreceptor in vivo. Br.J.Pharmacol. 124 206 PMID: 9630361

Corradetti et al (1998) Antagonist properties of (-)-pindolol and WAY 100635 at somatodendritic and postsynaptic 5-HT1A receptors in the rat brain. Br.J.Pharmacol. 123 449 PMID: 9504386

Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165

Merck Index 12 7597

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Literature in this Area

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