(S)-(+)-Niguldipine hydrochloride

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Cat.No. 1123 - (S)-(+)-Niguldipine hydrochloride | C36H39N3O6.HCl | CAS No. 113145-69-0
Description: α1 antagonist, L-type Ca2+ channel blocker
Chemical Name: (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Datasheet
Citations
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Literature

Biological Activity

L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; more active enantiomer. (R)-(-)-Niguldipine hydrochloride (Cat. No. 1124) also available.

Compound Libraries

(S)-(+)-Niguldipine hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 646.18
Formula C36H39N3O6.HCl
Storage Desiccate at -20°C
CAS Number 113145-69-0
PubChem ID 6419995
InChI Key JTQJFSQQHGPLOX-UHFFFAOYSA-N
Smiles O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 64.62 100
ethanol 64.62 100

Preparing Stock Solutions

The following data is based on the product molecular weight 646.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.55 mL 7.74 mL 15.48 mL
5 mM 0.31 mL 1.55 mL 3.1 mL
10 mM 0.15 mL 0.77 mL 1.55 mL
50 mM 0.03 mL 0.15 mL 0.31 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973

Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182


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Citations for (S)-(+)-Niguldipine hydrochloride

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