(S)-(+)-Niguldipine hydrochloride

Discontinued Product

(S)-(+)-Niguldipine hydrochloride (Cat. No. 1123) has been withdrawn from sale for commercial reasons.
Description: α1 antagonist, L-type Ca2+ channel blocker
Chemical Name: (S)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Literature (4)

Biological Activity for (S)-(+)-Niguldipine hydrochloride

(S)-(+)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; more active enantiomer.

R-enantiomer also available.

Technical Data for (S)-(+)-Niguldipine hydrochloride

M. Wt 646.18
Formula C36H39N3O6.HCl
Storage Desiccate at -20°C
CAS Number 113145-69-0
PubChem ID 6419995
Smiles O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for (S)-(+)-Niguldipine hydrochloride

References for (S)-(+)-Niguldipine hydrochloride

References are publications that support the biological activity of the product.

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973

Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182

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Citations for (S)-(+)-Niguldipine hydrochloride

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Currently there are no citations for (S)-(+)-Niguldipine hydrochloride.

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