(R)-(-)-Niguldipine hydrochloride

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Cat.No. 1124 - (R)-(-)-Niguldipine hydrochloride | C36H39N3O6.HCl | CAS No. 113145-70-3
Description: α1 antagonist, L-type Ca2+ channel blocker. Less active enantiomer of Niguldipine hydrochloride (Cat. No. 1123)
Chemical Name: (R)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid, 3-(4,4-diphenyl-1-piperidinyl)propyl methyl ester hydrochloride
Literature (4)

Biological Activity for (R)-(-)-Niguldipine hydrochloride

(R)-(-)-Niguldipine hydrochloride is a L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; less active enantiomer.

S-enantiomer also available.

Technical Data for (R)-(-)-Niguldipine hydrochloride

M. Wt 646.18
Formula C36H39N3O6.HCl
Storage Desiccate at -20°C
CAS Number 113145-70-3
PubChem ID 16219720
Smiles O=C(OC)C1=C(C)NC(C)=C(C(OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3)=O)[C@@H]1[C@]2=CC=CC([N+]([O-])=O)=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(-)-Niguldipine hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
water 10

Preparing Stock Solutions for (R)-(-)-Niguldipine hydrochloride

The following data is based on the product molecular weight 646.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.48 mL 77.38 mL 154.76 mL
0.5 mM 3.1 mL 15.48 mL 30.95 mL
1 mM 1.55 mL 7.74 mL 15.48 mL
5 mM 0.31 mL 1.55 mL 3.1 mL

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Product Datasheets for (R)-(-)-Niguldipine hydrochloride

References for (R)-(-)-Niguldipine hydrochloride

References are publications that support the biological activity of the product.

Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881

Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206

Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973

Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182

If you know of a relevant reference for (R)-(-)-Niguldipine hydrochloride, please let us know.

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Citations for (R)-(-)-Niguldipine hydrochloride

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