L-type Ca2+ channel blocker and α1A-adrenoceptor antagonist; less active enantiomer.
S-enantiomer also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 10 mM in water|
References are publications that support the biological activity of the product.
Boer et al (1989) (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of alpha1-adrenoceptor. Eur.J.Pharmacol. 172 131 PMID: 2548881
Graziadei et al (1989) Stereoselective binding of niguldipine enantiomers to alpha1A-adrenoceptors labeled with [3H]5-methyl-urapidil. Eur.J.Pharmacol. 172 329 PMID: 2555206
Hollt et al (1992) Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 43 2601 PMID: 1352973
Wetzel et al (1995) Discovery of alpha1a-adrenergic receptor antagonists based on the L-type Ca2+ channel antagonist niguldipine. J.Med.Chem. 38 1579 PMID: 7752182
If you know of a relevant reference for (R)-(-)-Niguldipine hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: (R)-(-)-Niguldipine hydrochloride, (R)-(-)-Niguldipine hydrochloride supplier, Ca2+, channel, blocker, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Adrenergic, Alpha-1, Cav1.x, 1124, Tocris Bioscience
Citations for (R)-(-)-Niguldipine hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for (R)-(-)-Niguldipine hydrochloride. Do you know of a great paper that uses (R)-(-)-Niguldipine hydrochloride from Tocris? Please let us know.
Reviews for (R)-(-)-Niguldipine hydrochloride
There are currently no reviews for this product. Be the first to review (R)-(-)-Niguldipine hydrochloride and earn rewards!
Have you used (R)-(-)-Niguldipine hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.