Rose Bengal

Discontinued Product

Rose Bengal (Cat. No. 5168) has been withdrawn from sale for commercial reasons.
Description: Stains exposed epithelium in eye. Also VGlut and VMAT inhibitor
Chemical Name: 4,5,6,7-Tetrachloro-3',6'-dihydroxy-2',4',5',7'-tetraiodo-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one disodium salt
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Reviews (1)
Literature (1)

Biological Activity for Rose Bengal

Rose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.

Technical Data for Rose Bengal

M. Wt 1017.64
Formula C20H2Cl4I4Na2O5
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 632-69-9
PubChem ID 32343
InChI Key UWBXIFCTIZXXLS-UHFFFAOYSA-L
Smiles O=C2C(I)=CC(C(OC3=C(I)C(O[Na])=C(I)C=C34)=C2I)=C4C1=C(C(O[Na])=O)C(Cl)=C(Cl)C(Cl)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Rose Bengal

References are publications that support the biological activity of the product.

Pietrancosta et al (2010) Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 18 6922 PMID: 20708942

Ogita et al (2001) Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 77 34 PMID: 11279259

Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 38 1060 PMID: 23303071

Feenstra et al (1992) What is actually stained by rose bengal? Arch.Ophthalmol. 110 984 PMID: 1637285

Keywords: Rose Bengal, Rose Bengal supplier, potent, non, competitive, inhibitors, inhibits, membrane, permeable, glutamate, vesicular, transporters, VGLUT, excitatory, amino, acid, neuroprotective, Rose, Bengal, Vesicular, Monoamine, Transporters, Labels, and, Stains, Fluorescent, Transporter, Probes, 5168, Tocris Bioscience

2 Citations for Rose Bengal

Citations are publications that use Tocris products. Selected citations for Rose Bengal include:

Richard et al (2022) Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience 25 103539 PMID: 34977503

Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483


Reviews for Rose Bengal

Average Rating: 5 (Based on 1 Review.)

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works well.
By Anonymous on 03/29/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: rat adrenal medulla chromaffin cells

100 μM

PMID: 30567483
review image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Fluorescent Dyes and Probes Research Product Guide

Fluorescent Dyes and Probes Research Product Guide

This product guide provides a background to the use of Fluorescent Dyes and Probes, as well as a comprehensive list of our:

  • Fluorescent Dyes, including dyes for flow cytometry
  • Fluorescent Probes and Stains, including our new MitoBrilliantTM mitochondria stains
  • Tissue Clearing Kits and Reagents
  • Aptamer-based RNA Imaging Reagents
  • Fluorescent Probes for Imaging Bacteria
  • TSA VividTM Fluorophore Kits
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals