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Submit ReviewRose Bengal is a potent VGlut and vesicular monoamine transporter (VMAT) inhibitor (Ki values are 19 and 64 nM, respectively). Inhibits ATP dependent vesicular glutamate uptake (IC50 = 37 nM) and diminishes the amount of exocytotically released glutamate in synaptosomes. Decreases synaptic transmission in the dentate gyrus. Also stains exposed epithelium in the eye. Cell permeable.
M. Wt | 1017.64 |
Formula | C20H2Cl4I4Na2O5 |
Storage | Store at RT |
Purity | ≥98% (HPLC) |
CAS Number | 632-69-9 |
PubChem ID | 32343 |
InChI Key | UWBXIFCTIZXXLS-UHFFFAOYSA-L |
Smiles | O=C2C(I)=CC(C(OC3=C(I)C(O[Na])=C(I)C=C34)=C2I)=C4C1=C(C(O[Na])=O)C(Cl)=C(Cl)C(Cl)=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Pietrancosta et al (2010) Rose Bengal analogs and vesicular glutamate transporters (VGLUTs). Bioorg.Med.Chem. 18 6922 PMID: 20708942
Ogita et al (2001) Inhibition of vesicular glutamate storage and exocytotic release by Rose Bengal. J Neurochem. 77 34 PMID: 11279259
Neale et al (2013) Modulation of hippocampal synaptic transmission by the kynurenine pathway member xanthurenic acid and other VGLUT inhibitors. Neuropsychopharmacology. Neuropsychopharmacology 38 1060 PMID: 23303071
Feenstra et al (1992) What is actually stained by rose bengal? Arch.Ophthalmol. 110 984 PMID: 1637285
Keywords: Rose Bengal, Rose Bengal supplier, potent, non, competitive, inhibitors, inhibits, membrane, permeable, glutamate, vesicular, transporters, VGLUT, excitatory, amino, acid, neuroprotective, Rose, Bengal, Vesicular, Monoamine, Transporters, Labels, and, Stains, Fluorescent, Transporter, Probes, 5168, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Rose Bengal include:
Ahmad et al (2019) Perivascular Adipocytes Store Norepinephrine by Vesicular Transport. Arterioscler Thromb Vasc Biol 39 188 PMID: 30567483
Richard et al (2022) Glycine-induced NMDA receptor internalization provides neuroprotection and preserves vasculature following ischemic stroke. iScience 25 103539 PMID: 34977503
Average Rating: 5 (Based on 1 Review.)
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