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Submit ReviewRhosin hydrochloride
Description: Rho inhibitor
Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Rhosin hydrochloride
Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.
Technical Data for Rhosin hydrochloride
| M. Wt | 394.86 |
| Formula | C20H18N6O.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1281870-42-5 |
| PubChem ID | 44662615 |
| InChI Key | SFRGBDFQSLZYLF-GRYLRVQNSA-N |
| Smiles | N[C@@H](C(N/N=C/C3=CC=C(N=CC=N4)C4=C3)=O)CC2=CNC1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Rhosin hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 7.9 | 20 with gentle warming | |
| DMSO | 39.49 | 100 |
Preparing Stock Solutions for Rhosin hydrochloride
The following data is based on the product molecular weight 394.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.53 mL | 12.66 mL | 25.33 mL |
| 5 mM | 0.51 mL | 2.53 mL | 5.07 mL |
| 10 mM | 0.25 mL | 1.27 mL | 2.53 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.51 mL |
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Product Datasheets for Rhosin hydrochloride
References for Rhosin hydrochloride
References are publications that support the biological activity of the product.
Shang et al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155 PMID: 23382194
Shang et al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699 PMID: 22726684
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Keywords: Rhosin hydrochloride, Rhosin hydrochloride supplier, Rho, GTPases, inhibitors, inhibits, guanine, nucleotide, exchange, factors, GEF, 5003, Tocris Bioscience
1 Citation for Rhosin hydrochloride
Citations are publications that use Tocris products. Selected citations for Rhosin hydrochloride include:
Ariyani et al (2022) Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway Sci.Rep 12 5850 PMID: 35393504
Do you know of a great paper that uses Rhosin hydrochloride from Tocris? Please let us know.
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