Rhosin hydrochloride

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Cat.No. 5003 - Rhosin hydrochloride | C20H18N6O.HCl | CAS No. 1281870-42-5
Description: Rho GTPase inhibitor
Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

Technical Data

M. Wt 394.86
Formula C20H18N6O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1281870-42-5
PubChem ID 44662615
InChI Key SFRGBDFQSLZYLF-GRYLRVQNSA-N
Smiles N[C@@H](C(N/N=C/C3=CC=C(N=CC=N4)C4=C3)=O)CC2=CNC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.49 100
water 7.9 20mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 394.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.66 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Shang et al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155 PMID: 23382194

Shang et al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699 PMID: 22726684


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Keywords: Rho GTPases inhibitors inhibits guanine nucleotide exchange factors GEF GTPase

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