Rhosin hydrochloride

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Description: Rho inhibitor
Chemical Name: D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (7)
Reviews

Biological Activity for Rhosin hydrochloride

Rhosin hydrochloride is a Rho GTPase inhibitor (Kd = 354 nM). Inhibits binding of RhoA to guanine nucleotide exchange factors (GEFs) including LARG, DBL, LBC, p115 RhoGEF and PDZ RhoGEF. Has no effect on the binding of Rac1 or Cdc42 to their respective GEFs. Suppresses RhoA/C-mediated breast cancer cell migration and invasion in vitro. Also induces neurite outgrowth in synergy with NGF.

Technical Data for Rhosin hydrochloride

M. Wt 394.86
Formula C20H18N6O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1281870-42-5
PubChem ID 44662615
InChI Key SFRGBDFQSLZYLF-GRYLRVQNSA-N
Smiles N[C@@H](C(N/N=C/C3=CC=C(N=CC=N4)C4=C3)=O)CC2=CNC1=CC=CC=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rhosin hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 7.9 20 with gentle warming
DMSO 39.49 100

Preparing Stock Solutions for Rhosin hydrochloride

The following data is based on the product molecular weight 394.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.66 mL 25.33 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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Product Datasheets for Rhosin hydrochloride

Certificate of Analysis / Product Datasheet
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References for Rhosin hydrochloride

References are publications that support the biological activity of the product.

Shang et al (2013) Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors. Proc.Natl.Acad.Sci.U.S.A. 110 3155 PMID: 23382194

Shang et al (2012) Rational design of small molecule inhibitors targeting RhoA subfamily Rho GTPases. Chem.Biol. 19 699 PMID: 22726684


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Keywords: Rhosin hydrochloride, Rhosin hydrochloride supplier, Rho, GTPases, inhibitors, inhibits, guanine, nucleotide, exchange, factors, GEF, 5003, Tocris Bioscience

7 Citations for Rhosin hydrochloride

Citations are publications that use Tocris products. Selected citations for Rhosin hydrochloride include:

Wenming et al (2021) Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection. Commun Biol 4 1239 PMID: 34716403

Ginam et al (2021) β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11 21477 PMID: 34728663

Ariyani et al (2022) Gadolinium-based contrast agent accelerates the migration of astrocyte via integrin αvβ3 signaling pathway Sci.Rep 12 5850 PMID: 35393504

Thomas et al (2023) Unique osteogenic profile of bone marrow stem cells stimulated in perfusion bioreactor is Rho-ROCK-mediated contractility dependent. Bioeng Transl Med 8 e10509 PMID: 37206242


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