Reversan

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Description: Selective MRP1 and P-gp inhibitor
Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)

Biological Activity for Reversan

Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Compound Libraries for Reversan

Reversan is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Reversan

M. Wt 441.52
Formula C26H27N5O2
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 313397-13-6
PubChem ID 2298706
InChI Key JTRXWCLQFAZHGP-UHFFFAOYSA-N
Smiles O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Reversan

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.04 25

Preparing Stock Solutions for Reversan

The following data is based on the product molecular weight 441.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.25 mM 9.06 mL 45.3 mL 90.6 mL
1.25 mM 1.81 mL 9.06 mL 18.12 mL
2.5 mM 0.91 mL 4.53 mL 9.06 mL
12.5 mM 0.18 mL 0.91 mL 1.81 mL

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References for Reversan

References are publications that support the biological activity of the product.

Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573 PMID: 19654298


If you know of a relevant reference for Reversan, please let us know.

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Keywords: Reversan, Reversan supplier, MRP1, p-glycoprotein, p-gp, multidrug, resistance, associated, protein, 1, transporters, inhibitors, inhibits, selective, ABCB1, Multidrug, Transporters, 3722, Tocris Bioscience

1 Citation for Reversan

Citations are publications that use Tocris products. Selected citations for Reversan include:

James E et al (2020) Roles of ABCC1 and ABCC4 in Proliferation and Migration of Breast Cancer Cell Lines. Int J Mol Sci 21 PMID: 33081264


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Reviews for Reversan

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Programmed Cell Death Poster

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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.