Reversan

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Cat.No. 3722 - Reversan | C26H27N5O2 | CAS No. 313397-13-6
Description: Selective MRP1 and P-gp inhibitor
Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations

Biological Activity

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Compound Libraries

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Technical Data

M. Wt 441.52
Formula C26H27N5O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 313397-13-6
PubChem ID 2298706
InChI Key JTRXWCLQFAZHGP-UHFFFAOYSA-N
Smiles O=C(NCCCN5CCOCC5)C2=C1N=C(C4=CC=CC=C4)C=C(C3=CC=CC=C3)N1N=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 11.04 25
ethanol 2.21 5

Preparing Stock Solutions

The following data is based on the product molecular weight 441.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.26 mL 11.32 mL 22.65 mL
5 mM 0.45 mL 2.26 mL 4.53 mL
10 mM 0.23 mL 1.13 mL 2.26 mL
50 mM 0.05 mL 0.23 mL 0.45 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Burkhart et al (2009) Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. Cancer Res. 69 6573 PMID: 19654298


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Keywords: MRP1 p-glycoprotein p-gp multidrug resistance associated protein 1 transporters inhibitors inhibits selective ABCB1 Multidrug Transporters

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