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Submit ReviewRCGD 423
Description: gp130 modulator; activates JAK/STAT signaling
Chemical Name: N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
Biological Activity for RCGD 423
RCGD 423 is a gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.
Compound Libraries for RCGD 423
RCGD 423 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
Technical Data for RCGD 423
| M. Wt | 331.23 |
| Formula | C15H11BrN2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 108237-91-8 |
| PubChem ID | 4456143 |
| InChI Key | OUFYYVAASPLOAA-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RCGD 423
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.12 | 100 | |
| ethanol | 33.12 | 100 |
Preparing Stock Solutions for RCGD 423
The following data is based on the product molecular weight 331.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.02 mL | 15.1 mL | 30.19 mL |
| 5 mM | 0.6 mL | 3.02 mL | 6.04 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.02 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for RCGD 423
References for RCGD 423
References are publications that support the biological activity of the product.
Flores et al (2017) Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat.Cell Biol. 19 1017 PMID: 28812580
Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS.Chem.Neurosci. 9 462 PMID: 29161500
If you know of a relevant reference for RCGD 423, please let us know.
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Citations for RCGD 423
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