RCGD 423

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Cat.No. 7066 - RCGD 423 | C15H11BrN2S | CAS No. 108237-91-8
Description: gp130 modulator; activates JAK/STAT signaling
Chemical Name: N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.

Technical Data

M. Wt 331.23
Formula C15H11BrN2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 108237-91-8
PubChem ID 4456143
InChI Key OUFYYVAASPLOAA-UHFFFAOYSA-N
Smiles BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.12 100
ethanol 33.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.1 mL 30.19 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References

References are publications that support the biological activity of the product.

Flores et al (2017) Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat.Cell Biol. 19 1017 PMID: 28812580

Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS.Chem.Neurosci. 9 462 PMID: 29161500


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