RCGD 423

Pricing Availability   Qty
Description: gp130 modulator; activates JAK/STAT signaling
Chemical Name: N-(4-Bromophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for RCGD 423

RCGD 423 is a gp130 modulator. Binds gp130, promotes Myc expression, increases lactate production and activates downstream JAK/STAT signaling pathways in hair follicle stem cells. Also increases articular chondrocyte activation and facilitates joint repair by regulating cartilage growth and differentiation.

Compound Libraries for RCGD 423

RCGD 423 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.

Technical Data for RCGD 423

M. Wt 331.23
Formula C15H11BrN2S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 108237-91-8
PubChem ID 4456143
Smiles BrC1=CC=C(C=C1)NC2=NC(C3=CC=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RCGD 423

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 33.12 100
ethanol 33.12 100

Preparing Stock Solutions for RCGD 423

The following data is based on the product molecular weight 331.23. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.1 mL 30.19 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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References for RCGD 423

References are publications that support the biological activity of the product.

Flores et al (2017) Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat.Cell Biol. 19 1017 PMID: 28812580

Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS.Chem.Neurosci. 9 462 PMID: 29161500

If you know of a relevant reference for RCGD 423, please let us know.

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Citations for RCGD 423

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Literature in this Area

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Rheumatoid Arthritis Poster

Rheumatoid Arthritis Poster

Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.