Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
Control Peptide also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 2 mg/ml in PBS (pH 7.4)|
Preparing Stock Solutions
The following data is based on the product molecular weight 1671.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.6 mL||2.99 mL||5.98 mL|
|5 mM||0.12 mL||0.6 mL||1.2 mL|
|10 mM||0.06 mL||0.3 mL||0.6 mL|
|50 mM||0.01 mL||0.06 mL||0.12 mL|
References are publications that support the products' biological activity.
Gao et al (2001) Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J.Biol.Chem. 276 47530 PMID: 11595749
If you know of a relevant reference for Rac1 Inhibitor W56, please let us know.
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Keywords: Rac1 Inhibitor W56, supplier, Selective, inhibitors, inhibits, Rac1-GEF, interaction, GTPases, G, Proteins, Small, G, Proteins, (Small), GTPase, G, Proteins, (Small), Tocris Bioscience
1 Citation for Rac1 Inhibitor W56
Citations are publications that use Tocris products. Selected citations for Rac1 Inhibitor W56 include:
Zeineddine et al (2015) SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Am J Physiol Lung Cell Mol Physiol 10 57 PMID: 26520394
Do you know of a great paper that uses Rac1 Inhibitor W56 from Tocris? If so please let us know.
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