Rac1 Inhibitor W56

Discontinued Product

Rac1 Inhibitor W56 (Cat. No. 2221) has been withdrawn from sale for commercial reasons.
Cat.No. 2221 - Rac1 Inhibitor W56 | Met-Val-Asp-Gly-Lys-Pro-Val-Asn-Leu-Gly-Leu-Trp-Asp-Thr-Ala-Gly | CAS No. 1095179-01-3
Description: Selective inhibitor of Rac1-GEF interaction
Datasheet
Citations (4)
Reviews

Biological Activity for Rac1 Inhibitor W56

Rac1 Inhibitor W56 is a peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.

Control Peptide also available.

Technical Data for Rac1 Inhibitor W56

M. Wt 1671.93
Formula C74H117N19O23S
Sequence MVDGKPVNLGLWDTAG
Storage Desiccate at -20°C
CAS Number 1095179-01-3
PubChem ID 90488750
InChI Key IRORVMNZPUKWEX-YRMQSWGASA-N
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Rac1 Inhibitor W56

Certificate of Analysis / Product Datasheet
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References for Rac1 Inhibitor W56

References are publications that support the biological activity of the product.

Gao et al (2001) Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J.Biol.Chem. 276 47530 PMID: 11595749

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Keywords: Rac1 Inhibitor W56, Rac1 Inhibitor W56 supplier, Selective, inhibitors, inhibits, Rac1-GEF, interaction, GTPases, G, Proteins, Small, Rho, 2221, Tocris Bioscience

4 Citations for Rac1 Inhibitor W56

Citations are publications that use Tocris products. Selected citations for Rac1 Inhibitor W56 include:

Kruppa et al (2018) Myosin VI-Dependent Actin Cages Encapsulate Parkin-Positive Damaged Mitochondria. Dev Cell 44 484 PMID: 29398621

Ikram et al (2018) Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against dox. in a biomimetic 3D lymphoma model. Oncotarget 9 2058 PMID: 29416753

Zeineddine et al (2015) SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Am J Physiol Lung Cell Mol Physiol 10 57 PMID: 26520394

Bessa et al (2019) Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas. Cell Death Dis 10 143 PMID: 30760703


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