Peptide comprising residues 45-60 of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1; selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1 and Tiam1.
Control Peptide also available.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solubility||Soluble to 2 mg/ml in PBS (pH 7.4)|
References are publications that support the biological activity of the product.
Gao et al (2001) Trp56 of Rac1 specifies interaction with a subset of guanine nucleotide exchange factors. J.Biol.Chem. 276 47530 PMID: 11595749
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Keywords: Rac1 Inhibitor W56, Rac1 Inhibitor W56 supplier, Selective, inhibitors, inhibits, Rac1-GEF, interaction, GTPases, G, Proteins, Small, Rho, 2221, Tocris Bioscience
2 Citations for Rac1 Inhibitor W56
Citations are publications that use Tocris products. Selected citations for Rac1 Inhibitor W56 include:
Ikram et al (2018) Co-targeting of Tiam1/Rac1 and Notch ameliorates chemoresistance against doxorubicin in a biomimetic 3D lymphoma model. Oncotarget 9 2058 PMID: 29416753
Zeineddine et al (2015) SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation. Am J Physiol Lung Cell Mol Physiol 10 57 PMID: 26520394
Do you know of a great paper that uses Rac1 Inhibitor W56 from Tocris? Please let us know.
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