(R)-(+)-Blebbistatin

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Cat.No. 1853 - (R)-(+)-Blebbistatin | C18H16N2O2 | CAS No. 1177356-70-5
Description: Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760)
Chemical Name: (3aR)-(+)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inactive enantiomer of the selective inhibitor of myosin II, (±)-blebbistatin (Cat. No. 1760).

Technical Data

M. Wt 292.34
Formula C18H16N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1177356-70-5
PubChem ID 6604910
InChI Key LZAXPYOBKSJSEX-SFHVURJKSA-N
Smiles O=C2[C@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 292.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.21 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337 PMID: 15548862

Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743 PMID: 12637748

Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515 PMID:


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Keywords: (R)-(+)-Blebbistatin, supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, (R)-(+)-Blebbistatin, Myosin, Tocris Bioscience

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