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Description: Selective inhibitor of myosin II ATPase activity. Inactive enantiomer of (±)-blebbistatin (Cat. No. 1760)
Chemical Name: (3aR)-(+)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one
Purity: ≥99% (HPLC)
Citations (3)

Biological Activity for (R)-(+)-Blebbistatin

(R)-(+)-Blebbistatin is an inactive enantiomer of the selective inhibitor of myosin II (±)-blebbistatin.

Active Enantiomer and Racemate also available.

Technical Data for (R)-(+)-Blebbistatin

M. Wt 292.34
Formula C18H16N2O2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 1177356-70-5
PubChem ID 6604910
Smiles O=C2[C@]3(O)C(N(C4=CC=CC=C4)CC3)=NC1=CC=C(C)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for (R)-(+)-Blebbistatin

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.23 100

Preparing Stock Solutions for (R)-(+)-Blebbistatin

The following data is based on the product molecular weight 292.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.42 mL 17.1 mL 34.21 mL
5 mM 0.68 mL 3.42 mL 6.84 mL
10 mM 0.34 mL 1.71 mL 3.42 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets for (R)-(+)-Blebbistatin

Certificate of Analysis / Product Datasheet
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References for (R)-(+)-Blebbistatin

References are publications that support the biological activity of the product.

Limouze et al (2004) Specificity of blebbistatin, an inhibitor of myosin II. J.Muscle Res.Cell Motil. 25 337 PMID: 15548862

Straight et al (2003) Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor. Science 299 1743 PMID: 12637748

Straight et al (2002) Dissecting cytokinesis with small molecules. Amer.Soc.Cell Biol.Abstr. 2515

If you know of a relevant reference for (R)-(+)-Blebbistatin, please let us know.

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Keywords: (R)-(+)-Blebbistatin, (R)-(+)-Blebbistatin supplier, Selective, inhibitors, inhibits, myosin, II, ATPase, (R)-(+)-Blebbistatin, Myosin, 1853, Tocris Bioscience

3 Citations for (R)-(+)-Blebbistatin

Citations are publications that use Tocris products. Selected citations for (R)-(+)-Blebbistatin include:

Nyholm et al (2009) A novel genetic mechanism regulates dorsolateral hinge-point formation during zebrafish cranial neurulation. J Cell Sci 122 2137 PMID: 19470582

Maître et al (2016) Asymmetric division of contractile domains couples cell positioning and fate specification. Nature 536 344 PMID: 27487217

Bzymek et al (2016) Real-time two- and three-dimensional imaging of monocyte motility and navigation on planar surfaces and in collagen matrices: roles of Rho. Sci Rep 6 25016 PMID: 27122054

Do you know of a great paper that uses (R)-(+)-Blebbistatin from Tocris? Please let us know.

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