(R)-2-Hydroxyglutaric acid disodium salt

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Cat.No. 6124 - (R)-2-Hydroxyglutaric acid disodium salt | C5H6Na2O5 | CAS No. 103404-90-6
Description: KDM4A inhibitor; also NF-κB activator
Alternative Names: D-α-hydroxyglutaric acid disodium salt
Chemical Name: (R)-2-Hydroxypentanedioic acid disodium salt
Datasheet
Citations
Reviews
Literature

Biological Activity

Oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells.

Technical Data

M. Wt 192.08
Formula C5H6Na2O5
Storage Store at -20°C
CAS Number 103404-90-6
PubChem ID 45489701
InChI Key DZHFTEDSQFPDPP-HWYNEVGZSA-L
Smiles O[C@@H](C(O[Na])=O)CCC(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 192.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.21 mL 26.03 mL 52.06 mL
5 mM 1.04 mL 5.21 mL 10.41 mL
10 mM 0.52 mL 2.6 mL 5.21 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Chen et al (2016) The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 6 32428 PMID: 27577048

Carbonneau et al (2016) The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 7 12700 PMID: 27624942


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Citations for (R)-2-Hydroxyglutaric acid disodium salt

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