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(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 192.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.21 mL||26.03 mL||52.06 mL|
|5 mM||1.04 mL||5.21 mL||10.41 mL|
|10 mM||0.52 mL||2.6 mL||5.21 mL|
|50 mM||0.1 mL||0.52 mL||1.04 mL|
References are publications that support the biological activity of the product.
Chen et al (2016) The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 6 32428 PMID: 27577048
Carbonneau et al (2016) The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 7 12700 PMID: 27624942
Mauer et al (2019) FTO controls reversible m6Am RNA methylation during snRNA biogenesis. Nat.Chem.Biol. 15 340 PMID: 30778204
If you know of a relevant reference for (R)-2-Hydroxyglutaric acid disodium salt, please let us know.
Keywords: (R)-2-Hydroxyglutaric acid disodium salt, (R)-2-Hydroxyglutaric acid disodium salt supplier, 2HG, D-2HG, oncometabolite, mutant, isocitrate, dehydrogenase, 1, 2, IDH1, IDH2, NF-KB, NF-kappaB, NF-κB, activators, activates, mTOR, mammalian, Target, of, Rapamycin, KDM4A, lysine, demethylases, inhibitors, inhibits, FTO, mRNA, N6-methyladenine, demethylase, RNA, D-alpha-hydroxyglutaric, acid, disodium, salt, Histone, Demethylases, NF-kB/IkB, Isocitrate, (IDH1), Other, Oxygenases/Oxidases, 6124, Tocris Bioscience
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Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including: