(R)-2-Hydroxyglutaric acid disodium salt

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Description: KDM4A inhibitor; also NF-κB activator
Alternative Names: D-α-hydroxyglutaric acid disodium salt
Chemical Name: (R)-2-Hydroxypentanedioic acid disodium salt
Literature (1)

Biological Activity

(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).

Technical Data

M. Wt 192.08
Formula C5H6Na2O5
Storage Store at -20°C
CAS Number 103404-90-6
PubChem ID 45489701
Smiles O[C@@H](C(O[Na])=O)CCC(O[Na])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 19.21 100

Preparing Stock Solutions

The following data is based on the product molecular weight 192.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.21 mL 26.03 mL 52.06 mL
5 mM 1.04 mL 5.21 mL 10.41 mL
10 mM 0.52 mL 2.6 mL 5.21 mL
50 mM 0.1 mL 0.52 mL 1.04 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Chen et al (2016) The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells. Sci.Rep. 6 32428 PMID: 27577048

Carbonneau et al (2016) The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat.Commun. 7 12700 PMID: 27624942

Mauer et al (2019) FTO controls reversible m6Am RNA methylation during snRNA biogenesis. Nat.Chem.Biol. 15 340 PMID: 30778204

If you know of a relevant reference for (R)-2-Hydroxyglutaric acid disodium salt, please let us know.

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Citations for (R)-2-Hydroxyglutaric acid disodium salt

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.