Quercetin

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Cat.No. 1125 - Quercetin | C15H10O7 | CAS No. 117-39-5
Description: Non-selective PI 3-kinase inhibitor
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors.

Technical Data

M. Wt 302.24
Formula C15H10O7
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 117-39-5
PubChem ID 5280343
InChI Key REFJWTPEDVJJIY-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 302.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.31 mL 16.54 mL 33.09 mL
5 mM 0.66 mL 3.31 mL 6.62 mL
10 mM 0.33 mL 1.65 mL 3.31 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183 PMID: 11877325

Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583 PMID: 6311542

Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227 PMID: 6091650

Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819 PMID: 11934824

Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952 PMID: 8069862

Merck Index 12 8216 PMID:


If you know of a relevant reference for Quercetin, please let us know.

View Related Products by Product Action

View all PI 3-kinase Inhibitors

Keywords: Non-Selective PI 3-kinase inhibitors inhibits GPR30 agonists non-selective 3-Kinase PI3K Akt Signaling Signalling PIP2 Inositol Lipids cAMP Receptors Estrogen receptors Phosphoinositide Kinases GPER PI 3-Kinase

2 Citations for Quercetin

Citations are publications that use Tocris products. Selected citations for Quercetin include:

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Neurochem Int 12 109 PMID: 26656090

Filone et al (2014) The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog 10 e1003904 PMID: 24516381


Do you know of a great paper that uses Quercetin from Tocris? If so please let us know.

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Pathways for Quercetin

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