Quercetin

Pricing Availability   Qty
Cat.No. 1125 - Quercetin | C15H10O7 | CAS No. 117-39-5
Description: Non-selective PI 3-kinase inhibitor
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors.

Technical Data

M. Wt 302.24
Formula C15H10O7
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 117-39-5
PubChem ID 5280343
InChI Key REFJWTPEDVJJIY-UHFFFAOYSA-N
Smiles OC1=CC(O)=C2C(OC(=C(O)C2=O)C2=CC=C(O)C(O)=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 100 mM in DMSO

References

References are publications that support the biological activity of the product.

Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183 PMID: 11877325

Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583 PMID: 6311542

Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227 PMID: 6091650

Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819 PMID: 11934824

Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952 PMID: 8069862

Merck Index 12 8216


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Keywords: Quercetin, Quercetin supplier, Non-Selective, PI, 3-kinase, inhibitors, inhibits, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases, GPER, (GPER), IRE1, 1125, Tocris Bioscience

3 Citations for Quercetin

Citations are publications that use Tocris products. Selected citations for Quercetin include:

Filone et al (2014) The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog 10 e1003904 PMID: 24516381

Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Neurochem Int 12 109 PMID: 26656090

Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475


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Literature in this Area

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