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Antitumor agent; induces apoptosis and inhibits synthesis of heat shock proteins. Inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Can also activate Ca2+ and K+ channels and behaves as an agonist at estrogen (GPER) receptors. Blocks cellular entry by influenza A virus via an interaction with hemaglutinin. Inhibits SARS-CoV 3CLpro (IC50 = 73 μM).
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 302.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.31 mL||16.54 mL||33.09 mL|
|5 mM||0.66 mL||3.31 mL||6.62 mL|
|10 mM||0.33 mL||1.65 mL||3.31 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the biological activity of the product.
Cermak et al (2002) The flavonol quercetin activates basolateral K+ channels in rat distal colon epithelium. Br.J.Pharmacol. 135 1183 PMID: 11877325
Graziani et al (1983) The effect of quercetin on the phosphorylation activity of the Rous sarcoma virus transforming gene product in vitro and in vivo. J.Biochem. 135 583 PMID: 6311542
Levy et al (1984) Tyrosine protein kinase activity in the DMBA-induced rat mammary tumor: inhibition by quercetin. Biochem.Biophys.Res.Commun. 123 1227 PMID: 6091650
Saponara et al (2002) Quercetin as a novel activator of L-type Ca2+ channels in rat tail artery smooth muscle cells. Br.J.Pharmacol. 135 1819 PMID: 11934824
Wei et al (1994) Induction of apoptosis by quercetin: involvement of heat shock protein. Cancer Res. 54 4952 PMID: 8069862
Wu et al (2015) Quercetin as an antiviral agent inhibits influenza A virus (IAV) entry. Viruses 8 6 PMID: 26712783
Nguyen et al (2012) Flavonoid-mediated inhibition of SARS coronavirus 3C-like protease expressed in Pichia pastoris. Biotechnol.Lett. 34 831 PMID: 22350287
If you know of a relevant reference for Quercetin, please let us know.
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Keywords: Quercetin, Quercetin supplier, Non-Selective, PI, 3-kinase, inhibitors, inhibits, GPR30, agonists, non-selective, 3-Kinase, PI3K, Akt, Signaling, Signalling, PIP2, Inositol, Lipids, cAMP, Receptors, Estrogen, receptors, Phosphoinositide, Kinases, GPER, antiviral, influenza, virus, SARS-Cov, coronavirus, 3CLpro, (GPER), IRE1, COVID-19, 3C, and, 3CL, Proteases, Influenza, Viruses, Coronavirus, 1125, Tocris Bioscience
3 Citations for Quercetin
Citations are publications that use Tocris products. Selected citations for Quercetin include:
Filone et al (2014) The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection. PLoS Pathog 10 e1003904 PMID: 24516381
Yao et al (2016) Clobetasol promotes remyelination in a mouse model of neuromyelitis optica. Acta Neuropathol Commun 4 42 PMID: 27117475
Rees et al (2016) Correlating chemical sensitivity and basal gene expression reveals mechanism of action. Neurochem Int 12 109 PMID: 26656090
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