QAQ dichloride

Pricing Availability Delivery Time Qty
Cat.No. 5470 - QAQ dichloride | C28H44Cl2N6O2
Description: Photoswitchable Nav, Kv and Cav channel blocker
Chemical Name: 2,2'-[1,2-Diazenediylbis(4,1-phenyleneimino)bis[N,N,N-triethyl-2-oxo-ethanaminium] dichloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.

Technical Data

M. Wt 567.59
Formula C28H44Cl2N6O2
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 91826091
InChI Key VHURBRSYOFCHNY-UHFFFAOYSA-N
Smiles O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.68 10
water 28.38 50

Preparing Stock Solutions

The following data is based on the product molecular weight 567.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.76 mL 8.81 mL 17.62 mL
5 mM 0.35 mL 1.76 mL 3.52 mL
10 mM 0.18 mL 0.88 mL 1.76 mL
50 mM 0.04 mL 0.18 mL 0.35 mL

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Reconstitution Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID: 22343342

Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609


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Keywords: QAQ dichloride, supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Photoswitchable, Ligands, Voltage-gated, Calcium, Channels, Voltage-Gated, Potassium, Channels, Voltage-gated, Sodium, Channels, Photoswitchable, Ligands, Tocris Bioscience

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Literature in this Area

Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels