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PKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 390.47. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.75 mM||3.41 mL||17.07 mL||34.15 mL|
|3.75 mM||0.68 mL||3.41 mL||6.83 mL|
|7.5 mM||0.34 mL||1.71 mL||3.41 mL|
|37.5 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Shen et al (2015) The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 356 686 PMID: 25449427
Wang et al (2015) K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 1237 PMID: 26590425
Wang et al (2014) Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. BioMed Res.Int. 2014 968027 PMID: 25136641
If you know of a relevant reference for Prostratin, please let us know.
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Keywords: Prostratin, Prostratin supplier, protein, kinase, C, activators, PKC, activation, NF-KB, Kappa, κ, differentiation, AML, orally, available, HIV, signaling, Protein, Kinase, NF-kB/IkB, 5739, Tocris Bioscience
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Literature in this Area
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