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Prostratin is a PKC activator. Inhibits growth and induces differentiation of AML cell lines. Enhances cytarabine-induced differentiation of AML cells. Inhibits tumorigenesis in KRAS mutant pancreatic cancer cells and reduces tumor growth in mouse pancreatic tumor models. Also NF-κB activator. Activates HIV gene expression in T cells. Orally available.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Shen et al (2015) The protein kinase C agonist prostratin induces differentiation of human myeloid leukemia cells and enhances cellular differentiation by chemotherapeutic agents. Cancer Lett. 356 686 PMID: 25449427
Wang et al (2015) K-Ras promotes tumorigenicity through suppression of non-canonical Wnt signaling. Cell 163 1237 PMID: 26590425
Wang et al (2014) Protein kinase D3 is essential for prostratin-activated transcription of integrated HIV-1 provirus promoter via NF-κB signaling pathway. BioMed Res.Int. 2014 968027 PMID: 25136641
Keywords: Prostratin, Prostratin supplier, protein, kinase, C, activators, PKC, activation, NF-KB, Kappa, κ, differentiation, AML, orally, available, HIV, signaling, Protein, Kinase, NF-kB/IkB, 5739, Tocris Bioscience
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