Propidium iodide
Biological Activity
Red-fluorescent DNA stain. Membrane impermeant to live cells; differentiates between live and dead cells in cell populations.
Technical Data
| M. Wt | 668.39 |
| Formula | C27H34I2N4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 25535-16-4 |
| PubChem ID | 104981 |
| InChI Key | XJMOSONTPMZWPB-UHFFFAOYSA-M |
| Smiles | NC4=CC1=C(C=C4)C3=C(C=C(N)C=C3)[N+](CCC[N+](CC)(CC)C)=C1C2=CC=CC=C2.[I-].[I-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 3.34 | 5mM with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 668.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.5 mL | 7.48 mL | 14.96 mL |
| 5 mM | 0.3 mL | 1.5 mL | 2.99 mL |
| 10 mM | 0.15 mL | 0.75 mL | 1.5 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.3 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Jeong et al (2013) SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J.Biol.Chem. 289 4135 PMID: 24368766
Sonnemann et al (2014) p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors. Br.J.Cancer 110 656 PMID: 24281001
Yun et al (2013) Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J.Biol.Chem. 289 1491 PMID: 24297180
If you know of a relevant reference for Propidium iodide, please let us know.
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Citations for Propidium iodide
Citations are publications that use Tocris products.
Currently there are no citations for Propidium iodide. Do you know of a great paper that uses Propidium iodide from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Apoptosis
- Cell Metabolism
- Epigenetics
- Fluorescent Imaging
- Signal Transduction
- Stem Cells
