Prochlorperazine dimaleate

Pricing Availability Delivery Time Qty
Cat.No. 3287 - Prochlorperazine dimaleate | C20H24ClN3S.2C4H4O4 | CAS No. 84-02-6
Description: D2 receptor antagonist. Also 5-HT3 and nAChR antagonist
Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Compound Libraries

Prochlorperazine dimaleate is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 606.09
Formula C20H24ClN3S.2C4H4O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 84-02-6
PubChem ID 5281032
InChI Key DSKIOWHQLUWFLG-SPIKMXEPSA-N
Smiles O=C(O)/C=C\C(O)=O.ClC4=CC2=C(C=C4)SC1=CC=CC=C1N2CCCN3CCN(C)CC3.O=C(O)/C=C\C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 15.15 25

Preparing Stock Solutions

The following data is based on the product molecular weight 606.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.65 mL 8.25 mL 16.5 mL
5 mM 0.33 mL 1.65 mL 3.3 mL
10 mM 0.16 mL 0.82 mL 1.65 mL
50 mM 0.03 mL 0.16 mL 0.33 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lummis and Baker (1997) Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors. Neuropharmacology 36 665 PMID: 9225292

Ghelardini et al (2004) Prochlorperazine induces central antinociception mediated by the muscarinic system. Pharmacol.Res. 50 351 PMID: 15225680

Satoh et al (2005) The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart. J.Pharm.Sci. 97 101 PMID:


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Keywords: D2 receptor antagonists 5-HT3 nAChR Dopamine Receptors serotonin dopaminergic D2 Receptors

1 Citation for Prochlorperazine dimaleate

Citations are publications that use Tocris products. Selected citations for Prochlorperazine dimaleate include:

Kenny et al (2015) Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy. Proc Natl Acad Sci U S A 6 6220 PMID: 25653139


Do you know of a great paper that uses Prochlorperazine dimaleate from Tocris? If so please let us know.

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Pathways for Prochlorperazine dimaleate

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