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TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat.No.4287).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 243.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||8.22 mL||41.1 mL||82.19 mL|
|2.5 mM||1.64 mL||8.22 mL||16.44 mL|
|5 mM||0.82 mL||4.11 mL||8.22 mL|
|25 mM||0.16 mL||0.82 mL||1.64 mL|
References are publications that support the biological activity of the product.
Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID: 15661881
Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID: 21962237
Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554
If you know of a relevant reference for CL 075, please let us know.
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Keywords: CL 075, CL 075 supplier, CL075, Toll-like, receptors, TLR8, agonists, agonism, Receptors, 6142, Tocris Bioscience
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