CL 075

Pricing Availability Delivery Time Qty
Cat.No. 6142 - CL 075 | C13H13N3S | CAS No. 256922-53-9
Description: TLR8 agonist
Chemical Name: 2-Propylthiazolo[4,5-c]quinolin-4-amine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat.No.4287).

Technical Data

M. Wt 243.33
Formula C13H13N3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 256922-53-9
PubChem ID 10198719
InChI Key NFYMGJSUKCDVJR-UHFFFAOYSA-N
Smiles CCCC1=NC2=C(N=C3C=CC=CC3=C2S1)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 12.17 50
ethanol 2.43 10

Preparing Stock Solutions

The following data is based on the product molecular weight 243.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.11 mL 20.55 mL 41.1 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
10 mM 0.41 mL 2.05 mL 4.11 mL
50 mM 0.08 mL 0.41 mL 0.82 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID: 15661881

Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID: 21962237

Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554


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Keywords: CL 075, supplier, CL075, Toll-like, receptors, TLR8, agonists, agonism, Toll-like, Receptors, Toll-like, Receptors, Tocris Bioscience

Citations for CL 075

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Pathways for CL 075

Toll-like Receptor

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.