CL 075

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Description: TLR8 agonist
Chemical Name: 2-Propylthiazolo[4,5-c]quinolin-4-amine
Purity: ≥98% (HPLC)
Citations (1)
Pathways (1)

Biological Activity for CL 075

CL 075 is a TLR8 agonist. Induces production of TNF-α and IL-12 from peripheral blood mononuclear cells (PBMCs). Promotes maturation of monocyte-derived dendritic cells in combination with Poly(I:C) (Cat. No. 4287).

Technical Data for CL 075

M. Wt 243.33
Formula C13H13N3S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 256922-53-9
PubChem ID 10198719
Smiles CCCC1=NC2=C(N=C3C=CC=CC3=C2S1)N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for CL 075

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 12.17 50
ethanol 2.43 10

Preparing Stock Solutions for CL 075

The following data is based on the product molecular weight 243.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.22 mL 41.1 mL 82.19 mL
2.5 mM 1.64 mL 8.22 mL 16.44 mL
5 mM 0.82 mL 4.11 mL 8.22 mL
25 mM 0.16 mL 0.82 mL 1.64 mL

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References for CL 075

References are publications that support the biological activity of the product.

Gorden et al (2005) Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8. J.Immunol. 174 1259 PMID: 15661881

Pang et al (2011) Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 12 55 PMID: 21962237

Spranger et al (2010) Generation of Th1-polarizing dendritic cells using the TLR7/8 agonist CL075. J.Immunol. 185 738 PMID: 20511554

If you know of a relevant reference for CL 075, please let us know.

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Keywords: CL 075, CL 075 supplier, CL075, Toll-like, receptors, TLR8, agonists, agonism, Receptors, 6142, Tocris Bioscience

1 Citation for CL 075

Citations are publications that use Tocris products. Selected citations for CL 075 include:

Mathieu et al (2019) The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids. Cell Stem Cell 24 621-636.e16 PMID: 30930145

Do you know of a great paper that uses CL 075 from Tocris? Please let us know.

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Pathways for CL 075

Toll-like Receptor Signaling Pathway

Toll-like Receptor Signaling Pathway

TLR signaling is involved in the cellular response to threatening molecules such as bacteria and viruses. It results in an inflammatory and immmunological response.