Discontinued Product

Pluripotin (Cat. No. 4433) has been withdrawn from sale for commercial reasons.
Description: Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
Alternative Names: SC1
Chemical Name: N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)
Protocols (1)
Literature (4)
Pathways (1)

Biological Activity for Pluripotin

Pluripotin is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).

Technical Data for Pluripotin

M. Wt 550.54
Formula C27H25F3N8O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 839707-37-8
PubChem ID 12003241
Smiles CN2C1=NC(NC4=CC(C)=NN4C)=NC=C1CN(C3=CC(NC(C5=CC(C(F)(F)F)=CC=C5)=O)=CC=C3C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Pluripotin

Certificate of Analysis / Product Datasheet
Select another batch:

References for Pluripotin

References are publications that support the biological activity of the product.

Wu and Ding et al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3 255

Chen et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266 PMID: 17088537

Mertins et al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099 PMID: 23437320

View Related Products by Product Action

View all ERK Inhibitors

Keywords: Pluripotin, Pluripotin supplier, dual, inhibitors, inhibits, extracellular, signal-regulated, kinase, 1, ERK1, MAPK3, mitogen-activated, protein, 3, RasGAP, mouse, murine, stem, cells, self-renewal, SC1, ERK, Stem, Cell, Proliferation, 4433, Tocris Bioscience

Citations for Pluripotin

Citations are publications that use Tocris products.

Currently there are no citations for Pluripotin.

Reviews for Pluripotin

There are currently no reviews for this product. Be the first to review Pluripotin and earn rewards!

Have you used Pluripotin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Protocols for Pluripotin

The following protocol features additional information for the use of Pluripotin (Cat. No. 4433).

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Cancer Research Product Guide

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Immunology Product Listing

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
MAPK Signaling Scientific Review

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for Pluripotin

MAPK Signaling Pathway

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.