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Cat.No. 4433 - Pluripotin | C27H25F3N8O2 | CAS No. 839707-37-8
Description: Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal
Alternative Names: SC1
Chemical Name: N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Purity: ≥98% (HPLC)

Biological Activity

Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).

Technical Data

M. Wt 550.54
Formula C27H25F3N8O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 839707-37-8
PubChem ID 12003241
Smiles CN2C1=NC(NC4=CC(C)=NN4C)=NC=C1CN(C3=CC(NC(C5=CC(C(F)(F)F)=CC=C5)=O)=CC=C3C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 13.76 25

Preparing Stock Solutions

The following data is based on the product molecular weight 550.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.82 mL 9.08 mL 18.16 mL
5 mM 0.36 mL 1.82 mL 3.63 mL
10 mM 0.18 mL 0.91 mL 1.82 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Wu and Ding et al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3 255 PMID:

Chen et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266 PMID: 17088537

Mertins et al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099 PMID: 23437320

If you know of a relevant reference for Pluripotin, please let us know.

View Related Products by Product Action

View all ERK Inhibitors

Keywords: Pluripotin, supplier, dual, inhibitors, inhibits, extracellular, signal-regulated, kinase, 1, ERK1, MAPK3, mitogen-activated, protein, kinase, 3, RasGAP, mouse, murine, stem, cells, self-renewal, SC1, SC1, ERK, Tocris Bioscience

Citations for Pluripotin

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MAPK Signaling

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MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for Pluripotin


MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.


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