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Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 550.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.25 mM||7.27 mL||36.33 mL||72.66 mL|
|1.25 mM||1.45 mL||7.27 mL||14.53 mL|
|2.5 mM||0.73 mL||3.63 mL||7.27 mL|
|12.5 mM||0.15 mL||0.73 mL||1.45 mL|
References are publications that support the biological activity of the product.
Wu and Ding et al (2006) Applying chemical tools to the discovery of novel regenerative medicine. Drug Discov.Today Technol. 3 255
Chen et al (2006) Self-renewal of embryonic stem cells by a small molecule. Proc.Natl.Acad.Sci.USA 103 17266 PMID: 17088537
Mertins et al (2013) A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept. PLoS One 8 e57099 PMID: 23437320
If you know of a relevant reference for Pluripotin, please let us know.
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Keywords: Pluripotin, Pluripotin supplier, dual, inhibitors, inhibits, extracellular, signal-regulated, kinase, 1, ERK1, MAPK3, mitogen-activated, protein, 3, RasGAP, mouse, murine, stem, cells, self-renewal, SC1, ERK, Stem, Cell, Proliferation, 4433, Tocris Bioscience
Citations for Pluripotin
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Protocols for Pluripotin
The following protocol features additional information for the use of Pluripotin (Cat. No. 4433).
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.