Pimonidazole

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Cat.No. 6182 - Pimonidazole | C11H18N4O3 | CAS No. 70132-50-2
Description: Hypoxia detection reagent
Chemical Name: α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature (1)

Biological Activity

Hypoxia detection reagent. Labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Technical Data

M. Wt 254.29
Formula C11H18N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 70132-50-2
PubChem ID 50981
InChI Key WVWOOAYQYLJEFD-UHFFFAOYSA-N
Smiles OC(CN1CCCCC1)CN2C=CN=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.43 100
ethanol 25.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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References

References are publications that support the biological activity of the product.

Sato et al (2016) Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression. PLoS One 11 e0165946 PMID: 27855169

Bennewith et al (2002) Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 62 6827 PMID: 12460894


If you know of a relevant reference for Pimonidazole, please let us know.

Keywords: Pimonidazole, Pimonidazole supplier, hypoxia, detection, detects, hypoxic, in, vivo, labels, labeling, Labels, and, Stains, Fluorescent, Cell, Indicators, Sensors, 6182, Tocris Bioscience

Citations for Pimonidazole

Citations are publications that use Tocris products.

Currently there are no citations for Pimonidazole. Do you know of a great paper that uses Pimonidazole from Tocris? Please let us know.

Reviews for Pimonidazole

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PIMO detects the levels of hypoxia in Glioblastoma 3D spheres.
By sara Azeem on 01/08/2020
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: E2

Glioblstoma patient derived cell line E2 was cultured in a 3D model for 21 days and the level of hypoxia in the spheres were measured following treatment with Pimonidazole.

review image

Literature in this Area

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New Product Guide [Spring/Summer 2019]

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