Pimonidazole

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Cat.No. 6182 - Pimonidazole | C11H18N4O3 | CAS No. 70132-50-2
Description: Hypoxia detection reagent
Chemical Name: α-[(2-Nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Hypoxia detection reagent. Labels hypoxic tumor cells in vivo. Also labels hypoxic mesenchymal stem cells in mouse bone marrow.

Technical Data

M. Wt 254.29
Formula C11H18N4O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 70132-50-2
PubChem ID 50981
InChI Key WVWOOAYQYLJEFD-UHFFFAOYSA-N
Smiles OC(CN1CCCCC1)CN2C=CN=C2[N+]([O-])=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 25.43 100
ethanol 25.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 254.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.93 mL 19.66 mL 39.33 mL
5 mM 0.79 mL 3.93 mL 7.87 mL
10 mM 0.39 mL 1.97 mL 3.93 mL
50 mM 0.08 mL 0.39 mL 0.79 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Sato et al (2016) Notch2 signaling regulates the proliferation of murine bone marrow-derived mesenchymal stem/stromal cells via c-Myc expression. PLoS One 11 e0165946 PMID: 27855169

Bennewith et al (2002) Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 62 6827 PMID: 12460894


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Keywords: Pimonidazole, Pimonidazole supplier, hypoxia, detection, detects, hypoxic, in, vivo, labels, labeling, Labels, and, Stains, 6182, Tocris Bioscience

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Literature in this Area

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New Product Guide (Spring/Summer 2018)

Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.

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