PHT 427

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Cat.No. 4598 - PHT 427 | CAS No. 1191951-57-1
Description: Dual Akt and PDK1 inhibitor; antitumor
Chemical Name: 4-Dodecyl-N-1,3,4-thiadiazol-2-yl-benzenesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Dual Akt and PDK1 inhibitor; binds the pleckstrin homology (PH) domain of Akt and PDK1 (Ki values are 2.7 and 5.2 μM, respectively). Inhibits Akt phosphorylation and Akt downstream targets; also induces apoptosis in vitro. Displays synergistic antitumor effect when combined with chemotherapeutics in breast cancer mouse models.

Compound Libraries

PHT 427 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 409.61
Formula C20H31N3O2S2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1191951-57-1
PubChem ID 44240850
InChI Key BYWWNRBKPCPJMG-UHFFFAOYSA-N
Smiles O=S(C(C=C1)=CC=C1CCCCCCCCCCCC)(NC2=NN=CS2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 40.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 409.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.21 mL 24.41 mL
5 mM 0.49 mL 2.44 mL 4.88 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Moses et al (2009) In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Res. 69 5073 PMID: 19491272

Meuillet et al (2010) Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol.Cancer Ther. 9 706 PMID: 20197390


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Citations for PHT 427

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Literature in this Area

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Cancer Research Product Guide

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Pathways for PHT 427

Akt

Akt Signaling Pathway

The Akt signaling pathway plays a key role in the mediation of protein synthesis, metabolism, proliferation and cell cycle progression. It may be referred to as a 'prosurvival' pathway.

Protocols

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