Phospho-Glycogen Synthase Peptide-2 (substrate)

Pricing Availability Delivery Time Qty
Cat.No. 1352 - Phospho-Glycogen Synthase Peptide-2 (substrate) | Tyr-Arg-Arg-Ala-Ala-Val-Pro-Pro-Ser-Pro-Ser-Leu-Ser-Arg-His-Ser-Ser-Pro-His-Gln-Ser(OPO3H2)-Glu-Asp-Glu-Glu-Glu | CAS No. 851366-97-7
Description: Glycogen synthase kinase-3 substrate (synthetic)
Alternative Names: GS peptide-2
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Synthetic peptide suitable as a substrate for glycogen synthase kinase-3 (GSK-3).

Technical Data

M. Wt 3029
Formula C123H191N40O48P
Sequence YRRAAVPPSPSLSRHSSPHQSEDEEE

(Modifications: Ser-21 = OPO3H2)

Storage Desiccate at -20°C
CAS Number 851366-97-7
PubChem ID 90479786
InChI Key IIMKCITWGMPAKU-LKAJVXBKSA-N
Smiles [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 3029. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.33 mL 1.65 mL 3.3 mL
5 mM 0.07 mL 0.33 mL 0.66 mL
10 mM 0.03 mL 0.17 mL 0.33 mL
50 mM 0.01 mL 0.03 mL 0.07 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Sutherland et al (1993) Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth factor signalling. Biochem.J. 296 15 PMID: 8250835

Woodgett (1989) Use of peptide substrates for affinity purification of protein-serine kinases. Anal.Biochem. 180 237 PMID: 2554753


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Keywords: Phospho-Glycogen Synthase Peptide-2 (substrate), supplier, GSK-3, synthetic, Glycogen, synthase, kinase-3, kinases, Carbohydrate, Metabolism, Enzyme, Substrates, Activators, GSpeptide2, GS, peptide-2, Enzyme, Substrates, /, Activators, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Enzyme, Substrates, /, Activators, Tocris Bioscience

1 Citation for Phospho-Glycogen Synthase Peptide-2 (substrate)

Citations are publications that use Tocris products. Selected citations for Phospho-Glycogen Synthase Peptide-2 (substrate) include:

Stoothoff et al (2005) FRAT-2 preferentially increases glycogen synthase kinase 3 β-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. PLoS One 280 270 PMID: 15522877


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