PE 154

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Cat.No. 4086 - PE 154 | C35H35N5O4 | CAS No. 1192750-33-6
Description: Fluorescent, potent AChE and BChE inhibitor
Chemical Name: 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.

Technical Data

M. Wt 589.68
Formula C35H35N5O4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1192750-33-6
PubChem ID 90488911
InChI Key CYZIIGRHLSZNAV-SGWCAAJKSA-N
Smiles O=C(CC4=CC=C(N/C=C5/C(OC(C=C(N(CC)CC)C=C6)=C6C5=O)=O)C=C4)NNC2=C3C(CCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.48 50

Preparing Stock Solutions

The following data is based on the product molecular weight 589.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.48 mL 16.96 mL
5 mM 0.34 mL 1.7 mL 3.39 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kacza et al (2010) In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur.J.Neurosci. 31 99 PMID: 20092557

Elsinghorst et al (2009) A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org.Biomol.Chem. 7 3940 PMID: 19763296


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View all Cholinesterase Inhibitors

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1 Citation for PE 154

Citations are publications that use Tocris products. Selected citations for PE 154 include:

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176


Do you know of a great paper that uses PE 154 from Tocris? If so please let us know.

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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Alzheimer's Poster

Alzheimer's disease (AD) is a degenerative brain disease and the most common cause of dementia, affecting approximately 47 million people worldwide. Updated in 2015, this poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease, as well as classic AD drug targets.

Pathways for PE 154

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