PE 154

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Cat.No. 4086 - PE 154 | C35H35N5O4 | CAS No. 1192750-33-6
Description: Fluorescent, potent AChE and BChE inhibitor
Chemical Name: 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
Purity: ≥97% (HPLC)
Citations (1)

Biological Activity

Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.

Technical Data

M. Wt 589.68
Formula C35H35N5O4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1192750-33-6
PubChem ID 90488911
Smiles O=C(CC4=CC=C(N/C=C5/C(OC(C=C(N(CC)CC)C=C6)=C6C5=O)=O)C=C4)NNC2=C3C(CCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 29.48 50

Preparing Stock Solutions

The following data is based on the product molecular weight 589.68. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.39 mL 16.96 mL 33.92 mL
2.5 mM 0.68 mL 3.39 mL 6.78 mL
5 mM 0.34 mL 1.7 mL 3.39 mL
25 mM 0.07 mL 0.34 mL 0.68 mL

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References are publications that support the biological activity of the product.

Kacza et al (2010) In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur.J.Neurosci. 31 99 PMID: 20092557

Elsinghorst et al (2009) A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org.Biomol.Chem. 7 3940 PMID: 19763296

If you know of a relevant reference for PE 154, please let us know.

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View all Cholinesterase Inhibitors

Keywords: PE 154, PE 154 supplier, PE154, fluorescent, AChE, inhibitor, beta, amyloid, plaque, probe, probes, b-amyloid, acetylcholinesterase, inhibitors, inhibits, fluorescence, histochemistry, staining, labelling, Fluorescent, Ligands, Cholinesterases, 4086, Tocris Bioscience

1 Citation for PE 154

Citations are publications that use Tocris products. Selected citations for PE 154 include:

Zemkova et al (2011) Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

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