Home / Product Type / Fluorescence Imaging / Fluorescent Probes and Stains / Fluorescent Amyloid β Probes / PE 154

PE 154

Cat. No. 4086 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Cat.No. 4086 - PE 154 | C35H35N5O4 | CAS No. 1192750-33-6
Description: Targets and labels βamyloid plaques in histochemical analysis
Chemical Name: 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.

Technical Data

M. Wt 589.68
Formula C35H35N5O4
Storage Store at +4°C
Purity ≥97% (HPLC)
CAS Number 1192750-33-6
PubChem ID 90488911
InChI Key CYZIIGRHLSZNAV-SGWCAAJKSA-N
Smiles O=C(CC4=CC=C(N/C=C5/C(OC(C=C(N(CC)CC)C=C6)=C6C5=O)=O)C=C4)NNC2=C3C(CCCC3)=NC1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.48 50

Preparing Stock Solutions

The following data is based on the product molecular weight 589.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.39 mL 16.96 mL 33.92 mL
2.5 mM 0.68 mL 3.39 mL 6.78 mL
5 mM 0.34 mL 1.7 mL 3.39 mL
25 mM 0.07 mL 0.34 mL 0.68 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Kacza et al (2010) In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur.J.Neurosci. 31 99 PMID: 20092557

Elsinghorst et al (2009) A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org.Biomol.Chem. 7 3940 PMID: 19763296

If you know of a relevant reference for PE 154, please let us know.

View Related Products by Target

Keywords: PE 154, PE 154 supplier, PE154, fluorescent, AChE, inhibitor, beta, amyloid, plaque, probe, probes, b-amyloid, acetylcholinesterase, inhibitors, inhibits, fluorescence, histochemistry, staining, labelling, Cholinesterases, Fluorescent, Amyloid, B, Probes, Enzyme, and, Substrates, 4086, Tocris Bioscience

1 Citation for PE 154

Citations are publications that use Tocris products. Selected citations for PE 154 include:

Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176

Do you know of a great paper that uses PE 154 from Tocris? Please let us know.

Reviews for PE 154

There are currently no reviews for this product. Be the first to review PE 154 and earn rewards!

Have you used PE 154?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Fluorescent Probes and Dyes

Fluorescent Probes and Dyes Research Product Guide

This product guide provides a comprehensive list and background to the use of Fluorescent Probes and Dyes

  • Fluorescent Dyes
  • Dyes for Flow Cytometry
  • Fluorescent Probes
  • Anti-fade Reagents
  • Bioluminescent Substrates
  • Fluorogenic Dyes for Light-Up Aptamers
  • Fluorescent Probes for Imaging Bacteria
  • TSA Reagents for Enhancing IHC, ICC & FISH Signals