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Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 589.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||3.39 mL||16.96 mL||33.92 mL|
|2.5 mM||0.68 mL||3.39 mL||6.78 mL|
|5 mM||0.34 mL||1.7 mL||3.39 mL|
|25 mM||0.07 mL||0.34 mL||0.68 mL|
References are publications that support the biological activity of the product.
Kacza et al (2010) In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur.J.Neurosci. 31 99 PMID: 20092557
Elsinghorst et al (2009) A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org.Biomol.Chem. 7 3940 PMID: 19763296
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Keywords: PE 154, PE 154 supplier, PE154, fluorescent, AChE, inhibitor, beta, amyloid, plaque, probe, probes, b-amyloid, acetylcholinesterase, inhibitors, inhibits, fluorescence, histochemistry, staining, labelling, Cholinesterases, Fluorescent, Amyloid, B, Probes, Enzyme, and, Substrates, 4086, Tocris Bioscience
1 Citation for PE 154
Citations are publications that use Tocris products. Selected citations for PE 154 include:
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
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Literature in this Area
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