Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPotent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.
M. Wt | 589.68 |
Formula | C35H35N5O4 |
Storage | Store at +4°C |
Purity | ≥97% (HPLC) |
CAS Number | 1192750-33-6 |
PubChem ID | 90488911 |
InChI Key | CYZIIGRHLSZNAV-SGWCAAJKSA-N |
Smiles | O=C(CC4=CC=C(N/C=C5/C(OC(C=C(N(CC)CC)C=C6)=C6C5=O)=O)C=C4)NNC2=C3C(CCCC3)=NC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.48 | 50 |
The following data is based on the product molecular weight 589.68. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.5 mM | 3.39 mL | 16.96 mL | 33.92 mL |
2.5 mM | 0.68 mL | 3.39 mL | 6.78 mL |
5 mM | 0.34 mL | 1.7 mL | 3.39 mL |
25 mM | 0.07 mL | 0.34 mL | 0.68 mL |
References are publications that support the biological activity of the product.
Kacza et al (2010) In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. Eur.J.Neurosci. 31 99 PMID: 20092557
Elsinghorst et al (2009) A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques. Org.Biomol.Chem. 7 3940 PMID: 19763296
If you know of a relevant reference for PE 154, please let us know.
Keywords: PE 154, PE 154 supplier, PE154, fluorescent, AChE, inhibitor, beta, amyloid, plaque, probe, probes, b-amyloid, acetylcholinesterase, inhibitors, inhibits, fluorescence, histochemistry, staining, labelling, Cholinesterases, Fluorescent, Amyloid, B, Probes, Enzyme, and, Substrates, 4086, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for PE 154 include:
Zemkova et al (2011) NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology 152 3842 PMID: 21828176
Do you know of a great paper that uses PE 154 from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review PE 154 and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
This product guide provides a comprehensive list and background to the use of Fluorescent Probes and Dyes