Pricing Availability   Qty
Cat.No. 0238 - O-Phospho-L-serine | C3H8NO6P | CAS No. 407-41-0
Description: Group III mGlu agonist
Alternative Names: L-SOP
Chemical Name: L-Serine-O-phosphate
Citations (2)
Literature (8)

Biological Activity for O-Phospho-L-serine

O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.

Technical Data for O-Phospho-L-serine

M. Wt 185.07
Formula C3H8NO6P
Storage Store at RT
CAS Number 407-41-0
PubChem ID 68841
Smiles [H][C@@](COP(O)(O)=O)(N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for O-Phospho-L-serine

Solvent Max Conc. mg/mL Max Conc. mM
water 18.51 100

Preparing Stock Solutions for O-Phospho-L-serine

The following data is based on the product molecular weight 185.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 5.4 mL 27.02 mL 54.03 mL
5 mM 1.08 mL 5.4 mL 10.81 mL
10 mM 0.54 mL 2.7 mL 5.4 mL
50 mM 0.11 mL 0.54 mL 1.08 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for O-Phospho-L-serine

References for O-Phospho-L-serine

References are publications that support the biological activity of the product.

Bruno et al (1996) Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 310 61 PMID: 8880068

Eriksen and Thomsen (1995) [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 116 3279 PMID: 8719808

Thoreson and Ulphani (1995) Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 676 93 PMID: 7796182

Saxe et al (2007) A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 14 1019 PMID: 17884634

Yang et al (2016) A chemical biology route to site-specific authentic protein modifications. Science 354 623 PMID: 27708052

Park et al (2011) Expanding the genetic code of Escherichia coli with phosphoserine. Science 333 1151 PMID: 21868676

If you know of a relevant reference for O-Phospho-L-serine, please let us know.

View Related Products by Product Action

View all Glutamate (Metabotropic) Group III Receptor Agonists

Keywords: O-Phospho-L-serine, O-Phospho-L-serine supplier, Group, III, mGlur, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, stem, cells, o-phosphoserine, sep, L-SOP, (Metabotropic), Neural, Stem, Cells, 0238, Tocris Bioscience

2 Citations for O-Phospho-L-serine

Citations are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:

Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952

Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138 1026 PMID: 12684257

Do you know of a great paper that uses O-Phospho-L-serine from Tocris? Please let us know.

Reviews for O-Phospho-L-serine

There are currently no reviews for this product. Be the first to review O-Phospho-L-serine and earn rewards!

Have you used O-Phospho-L-serine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Metabotropic Glutamate Receptors

Metabotropic Glutamate Receptors Scientific Review

Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.

Learning & Memory

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.


Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.