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Biological Activity for O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4 (Cat. No. 0103). Neuroprotective against excitotoxicity in cortical cell cultures. Inhibits proliferation and enhances neuronal differentiation in progenitor cells.
Technical Data for O-Phospho-L-serine
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for O-Phospho-L-serine
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for O-Phospho-L-serine
The following data is based on the product molecular weight 185.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||5.4 mL||27.02 mL||54.03 mL|
|5 mM||1.08 mL||5.4 mL||10.81 mL|
|10 mM||0.54 mL||2.7 mL||5.4 mL|
|50 mM||0.11 mL||0.54 mL||1.08 mL|
Product Datasheets for O-Phospho-L-serine
References for O-Phospho-L-serine
References are publications that support the biological activity of the product.
Bruno et al (1996) Activation of group III metabotropic glutamate receptors is neuroprotective in cortical cultures. Eur.J.Pharmacol. 310 61 PMID: 8880068
Eriksen and Thomsen (1995) [3H]-L-2-amino-4-phosphonobutyrate labels a metabotropic glutamate receptor, mGluR4a. Br.J.Pharmacol. 116 3279 PMID: 8719808
Thoreson and Ulphani (1995) Pharmacology of selective and non-selective metabotropic glutamate receptor agonists at L-AP4 receptors in ON bipolar cells. Brain Res. 676 93 PMID: 7796182
Saxe et al (2007) A phenotypic small-molecule screen identifies an orphan ligand-receptor pair that regulates neural stem cell differentiation. Chem.Biol. 14 1019 PMID: 17884634
Yang et al (2016) A chemical biology route to site-specific authentic protein modifications. Science 354 623 PMID: 27708052
Park et al (2011) Expanding the genetic code of Escherichia coli with phosphoserine. Science 333 1151 PMID: 21868676
If you know of a relevant reference for O-Phospho-L-serine, please let us know.
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Keywords: O-Phospho-L-serine, O-Phospho-L-serine supplier, Group, III, mGlur, agonists, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, stem, cells, o-phosphoserine, sep, L-SOP, (Metabotropic), Neural, Stem, Cells, 0238, Tocris Bioscience
2 Citations for O-Phospho-L-serine
Citations are publications that use Tocris products. Selected citations for O-Phospho-L-serine include:
Jiang et al (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci 26 4318 PMID: 16624952
Mathiesen et al (2003) Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br J Pharmacol 138 1026 PMID: 12684257
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Learning & Memory Poster
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Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.