NSC 23005 sodium

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Cat.No. 5779 - NSC 23005 sodium | C13H16NNaO4S | CAS No. 1796596-46-7
Description: Potently promotes HSC expansion ; p18INK inhibitor
Chemical Name: 4-[(Cyclohexylamino)sulfonyl]benzoic acid sodium salt
Purity: ≥99% (HPLC)
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Literature

Biological Activity

p18INK inhibitor. Potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Exhibits no effect on leukemia cell proliferation.

Compound Libraries

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Technical Data

M. Wt 305.33
Formula C13H16NNaO4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1796596-46-7
PubChem ID 122705986
InChI Key MLHFBDVMTRIQMW-UHFFFAOYSA-M
Smiles O=S(C1=CC=C(C([O-])=O)C=C1)(NC2CCCCC2)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 30.53 100
DMSO 30.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454


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