NSC 23005 sodium

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Cat.No. 5779 - NSC 23005 sodium | C13H16NNaO4S | CAS No. 1796596-46-7
Description: Potently promotes HSC expansion ; p18INK inhibitor
Chemical Name: 4-[(Cyclohexylamino)sulfonyl]benzoic acid sodium salt
Purity: ≥99% (HPLC)

Biological Activity

p18INK inhibitor. Potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Exhibits no effect on leukemia cell proliferation.

Technical Data

M. Wt 305.33
Formula C13H16NNaO4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1796596-46-7
PubChem ID 122705986
Smiles O=S(C1=CC=C(C([O-])=O)C=C1)(NC2CCCCC2)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.53 100
ethanol 6.11 20
water 30.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454

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Citations for NSC 23005 sodium

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Literature in this Area


Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
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Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

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