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NSC 23005 sodium is a p18INK inhibitor. Potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Exhibits no effect on leukemia cell proliferation.
NSC 23005 sodium is also offered as part of the Tocriscreen Stem Cell Library. Find out more about compound libraries available from Tocris.
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Stem cells have potential as a source of cells and tissues for research and treatment of disease. This poster summarizes some key protocols demonstrating the use of small molecules across the stem cell workflow, from reprogramming, through self-renewal, storage and differentiation to verification. Advantages of using small molecules are also highlighted.