NSC 23005 sodium

Pricing Availability Delivery Time Qty
Cat.No. 5779 - NSC 23005 sodium | C13H16NNaO4S | CAS No. 1796596-46-7
Description: Potently promotes HSC expansion ; p18INK inhibitor
Chemical Name: 4-[(Cyclohexylamino)sulfonyl]benzoic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

p18INK inhibitor. Potently promotes hematopoietic stem cell (HSC) expansion (ED50 = 5.21 nM). Exhibits no effect on leukemia cell proliferation.

Technical Data

M. Wt 305.33
Formula C13H16NNaO4S
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1796596-46-7
PubChem ID 122705986
InChI Key MLHFBDVMTRIQMW-UHFFFAOYSA-M
Smiles O=S(C1=CC=C(C([O-])=O)C=C1)(NC2CCCCC2)=O.[Na+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.53 100
ethanol 6.11 20
water 30.53 100

Preparing Stock Solutions

The following data is based on the product molecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.75 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Xie et al (2015) Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci.Rep. 5 18115 PMID: 26681454


If you know of a relevant reference for NSC 23005 sodium, please let us know.

Keywords: NSC 23005 sodium, supplier, NSC23005, sodium, potently, promotes, HSC, expansion, p18INK, inhibitors, inhibits, cell, cycle, G1, phase, hematopoietic, stem, cells, Stem, Cell, Proliferation, Tocris Bioscience

Citations for NSC 23005 sodium

Citations are publications that use Tocris products.

Currently there are no citations for NSC 23005 sodium. Do you know of a great paper that uses NSC 23005 sodium from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Stem Cells

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Pathways for NSC 23005 sodium

Protocols

TODO: Add Protocols