(-)-Quinpirole hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 1061 - (-)-Quinpirole hydrochloride | C13H21N3.HCl | CAS No. 85798-08-9
Description: Selective D2-like agonist
Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (21)
Reviews
Literature

Biological Activity

Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).

Licensing Information

Sold with the permission of Eli Lilly and Company

Compound Libraries

(-)-Quinpirole hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 255.79
Formula C13H21N3.HCl
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 85798-08-9
PubChem ID 55397
InChI Key HJHVRVJTYPKTHX-HTMVYDOJSA-N
Smiles Cl.[H][C@]12CCCN(CCC)[C@]1([H])CC1=CNN=C1C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 6.39 25
water 25.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 255.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.91 mL 19.55 mL 39.09 mL
5 mM 0.78 mL 3.91 mL 7.82 mL
10 mM 0.39 mL 1.95 mL 3.91 mL
50 mM 0.08 mL 0.39 mL 0.78 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Levant et al (1996) Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site. J.Pharmacol.Exp.Ther. 278 145 PMID: 8764345

Seeman and Van Tol (1994) Dopamine receptor pharmacology. Trends Pharmacol.Sci. 15 264 PMID: 7940991

Sullivan et al (1998) Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience 83 781 PMID: 9483561


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Keywords: (-)-Quinpirole hydrochloride, supplier, Selective, D2-like, agonists, Dopamine, Non-Selective, Receptors, dopaminergic, Non-selective, Dopamine, Non-selective, Dopamine, Tocris Bioscience

21 Citations for (-)-Quinpirole hydrochloride

Citations are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

Borgs et al (2016) Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects. Scientific Reports 6 33377 PMID: 27640816

Picton et al (2016) Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles. Scientific Reports 6 35749 PMID: 27760989

Tozzi et al (2015) Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system. Front Cell Neurosci 9 192 PMID: 26074768

Wang et al (2015) A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. Proc Natl Acad Sci U S A 11 2057 PMID: 26649942

Shin et al (2015) Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens. Nat Neurosci 112 8124 PMID: 26080439

Xing et al (2015) Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells. Neuropsychopharmacology 9 310 PMID: 26388722

Ahmadiantehrani and Ron (2013) Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268. J Neurochem PMID: 23373701

Hutchinson et al (2012) Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Eur J Neurosci 37 321 PMID: 21956448

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Autophagy 35 507 PMID: 22304466

Ferraro et al (2012) A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study. J Neurosci 37 1856 PMID: 22453136

Gantz et al (2011) Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway. J Neurosci 31 12629 PMID: 21880923

Yoon et al (2011) Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation. Neuropsychopharmacology 286 15641 PMID: 21454669

Marchese et al (2003) Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications. Br J Pharmacol 140 520 PMID: 12970091

Burgess et al (2010) Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy. Sleep 33 1295 PMID: 21061851

Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958 PMID: 20601948

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. Neuron 30 2935 PMID: 20181591

Deng et al (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. J Biol Chem 13 1128 PMID: 20711186

Chuhma et al (2009) Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection. Neuroscience 164 1068 PMID: 19729052

Zapata et al (2007) Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors. J Biol Chem 282 35842 PMID: 17923483

Kitada et al (2007) Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A 104 11441 PMID: 17563363

González-Maeso et al (2007) Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior. PLoS One 53 439 PMID: 17270739


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