NAV 2729

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Description: Selective ARF6 inhibitor
Chemical Name: 3-(4-Chlorophenyl)-5-(4-nitrophenyl)-2-(phenylmethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity: ≥98% (HPLC)
Citations (5)

Biological Activity for NAV 2729

NAV 2729 is a selective ARF6 inhibitor (IC50 = 1.0 μM). Selective for ARF6 over other ARF family members and small GTPases. Inhibits ARF6 activation in uveal melanoma cells in vitro and blocks downstream signaling pathways of oncogenic GNAQ. Reduces tumorigenesis in mouse model of uveal melanoma.

Compound Libraries for NAV 2729

NAV 2729 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NAV 2729

M. Wt 456.88
Formula C25H17ClN4O3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 419547-11-8
PubChem ID 2257249
Smiles ClC1=CC=C(C2=C3NC(C4=CC=C([N+]([O-])=O)C=C4)=CC(N3N=C2CC5=CC=CC=C5)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for NAV 2729

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 45.69 100

Preparing Stock Solutions for NAV 2729

The following data is based on the product molecular weight 456.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.19 mL 10.94 mL 21.89 mL
5 mM 0.44 mL 2.19 mL 4.38 mL
10 mM 0.22 mL 1.09 mL 2.19 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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Product Datasheets for NAV 2729

Certificate of Analysis / Product Datasheet
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References for NAV 2729

References are publications that support the biological activity of the product.

Yoo et al (2016) ARF6 is an actionable node that orchestrates oncogenic GNAQ signaling in uveal melanoma. Cancer Cell. 29 889 PMID: 27265506

If you know of a relevant reference for NAV 2729, please let us know.

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Keywords: NAV 2729, NAV 2729 supplier, NAV2729, small, G, proteins, Gαq, GTPases, inhibitors, inhibits, selective, ARF6, GNAQ, Arf, 5986, Tocris Bioscience

5 Citations for NAV 2729

Citations are publications that use Tocris products. Selected citations for NAV 2729 include:

Karlheinz et al (2020) Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients. Front Immunol 11 1789 PMID: 32983087

Ernst et al (2019) Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1. Blood Cancer J 9 6 PMID: 30647406

Gavin Y et al (2019) Bone Marrow-Derived Cells Restore Functional Integrity of the Gut Epithelial and Vascular Barriers in a Model of Diabetes and ACE2 Deficiency. Circ Res 125 969-988 PMID: 31610731

Finicle et al (2018) Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. J Cell Sci 131 PMID: 29848659

Do you know of a great paper that uses NAV 2729 from Tocris? Please let us know.

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