You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 539.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.27 mL||18.53 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.85 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420 PMID: 12939527
Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959 PMID: 12642398
Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105 PMID: 16815145
Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30 269 PMID: 32020029
If you know of a relevant reference for Nafamostat mesylate, please let us know.
View Related Products by Product Action
Keywords: Nafamostat mesylate, Nafamostat mesylate supplier, Serine, protease, inhibitors, inhibits, Proteases, Proteinases, SARS-CoV-2, COVI-19, severe, acute, respiratory, syndrome, Other, COVID-19, TMPRSS2, 3081, Tocris Bioscience
1 Citation for Nafamostat mesylate
Citations are publications that use Tocris products. Selected citations for Nafamostat mesylate include:
Scott et al (2018) Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep 8 3363 PMID: 29463838
Do you know of a great paper that uses Nafamostat mesylate from Tocris? Please let us know.
Reviews for Nafamostat mesylate
There are currently no reviews for this product. Be the first to review Nafamostat mesylate and earn rewards!
Have you used Nafamostat mesylate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Fluorescent Imaging
- Signal Transduction
- Stem Cells