Nafamostat mesylate

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Cat.No. 3081 - Nafamostat mesylate | C19H17N5O2.2CH4O3S | CAS No. 82956-11-4
Description: Serine protease inhibitor, inhibits tryptase
Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.

Compound Libraries

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Technical Data

M. Wt 539.59
Formula C19H17N5O2.2CH4O3S
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 82956-11-4
PubChem ID 54953
InChI Key SRXKIZXIRHMPFW-UHFFFAOYSA-N
Smiles CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 53.96 100
water 53.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 539.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420 PMID: 12939527

Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959 PMID: 12642398

Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105 PMID: 16815145


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Keywords: Nafamostat mesylate, supplier, Serine, protease, inhibitors, inhibits, Proteases, Proteinases, Other, Proteases, Other, Proteases, Tocris Bioscience

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