Nafamostat mesylate

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Description: Serine protease inhibitor; inhibits tryptase
Chemical Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Purity: ≥99% (HPLC)
Citations (1)
Reviews (1)

Biological Activity for Nafamostat mesylate

Nafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Nafamostat mesylate

Nafamostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Nafamostat mesylate

M. Wt 539.59
Formula C19H17N5O2.2CH4O3S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 82956-11-4
PubChem ID 54953
Smiles CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Nafamostat mesylate

Solvent Max Conc. mg/mL Max Conc. mM
water 53.96 100
DMSO 53.96 100

Preparing Stock Solutions for Nafamostat mesylate

The following data is based on the product molecular weight 539.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.85 mL 9.27 mL 18.53 mL
5 mM 0.37 mL 1.85 mL 3.71 mL
10 mM 0.19 mL 0.93 mL 1.85 mL
50 mM 0.04 mL 0.19 mL 0.37 mL

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Product Datasheets for Nafamostat mesylate

Certificate of Analysis / Product Datasheet
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References for Nafamostat mesylate

References are publications that support the biological activity of the product.

Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420 PMID: 12939527

Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959 PMID: 12642398

Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105 PMID: 16815145

Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30 269 PMID: 32020029

If you know of a relevant reference for Nafamostat mesylate, please let us know.

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Keywords: Nafamostat mesylate, Nafamostat mesylate supplier, Serine, protease, inhibitors, inhibits, Proteases, Proteinases, SARS-CoV-2, COVI-19, severe, acute, respiratory, syndrome, Other, COVID-19, TMPRSS2, Coronavirus, 3081, Tocris Bioscience

1 Citation for Nafamostat mesylate

Citations are publications that use Tocris products. Selected citations for Nafamostat mesylate include:

Scott et al (2018) Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep 8 3363 PMID: 29463838

Do you know of a great paper that uses Nafamostat mesylate from Tocris? Please let us know.

Reviews for Nafamostat mesylate

Average Rating: 3 (Based on 1 Review.)

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Used in cell culture.
By Anonymous on 11/19/2020
Species: Human
Cell Line/Tissue: ES cells

Used in cell culture to view the effects compared to others. Need qPCR to see results.