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Broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC50 = 22.50 μM).
Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 539.59. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.85 mL||9.27 mL||18.53 mL|
|5 mM||0.37 mL||1.85 mL||3.71 mL|
|10 mM||0.19 mL||0.93 mL||1.85 mL|
|50 mM||0.04 mL||0.19 mL||0.37 mL|
References are publications that support the biological activity of the product.
Mori et al (2003) Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 92 420 PMID: 12939527
Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 138 959 PMID: 12642398
Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 118 105 PMID: 16815145
Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30 269 PMID: 32020029
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Keywords: Nafamostat mesylate, Nafamostat mesylate supplier, Serine, protease, inhibitors, inhibits, Proteases, Proteinases, SARS-CoV-2, COVI-19, severe, acute, respiratory, syndrome, Other, COVID-19, TMPRSS2, Coronavirus, 3081, Tocris Bioscience
1 Citation for Nafamostat mesylate
Citations are publications that use Tocris products. Selected citations for Nafamostat mesylate include:
Scott et al (2018) Interleukin-33 is activated by allergen- and necrosis-associated proteolytic activities to regulate its alarmin activity during epithelial damage. Sci Rep 8 3363 PMID: 29463838
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Reviews for Nafamostat mesylate
Average Rating: 3 (Based on 1 Review.)
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Used in cell culture to view the effects compared to others. Need qPCR to see results.