Discontinued Product

Unfortunately MSOPPE (Cat. No. 0804) has been withdrawn from sale for commercial reasons.
Cat.No. 0804 - MSOPPE | CAS No. 170984-70-0
Description: Group II/group III mGlu antagonist. More selective for group II than group III
Chemical Name: (RS)-a-Methylserine-O-phosphate monophenyl ester

Biological Activity

mGlu receptor antagonist, slightly more selective for group II vs group III mGlu receptors. On primary afferent terminals in neonatal rat spinal cord, shows 3-fold greater selectivity for the (1S,3S)-ACPD-sensitive presynaptic receptor over the L-AP4-sensitive mGlu receptor (apparent KD values are 73 μM and 221 μM respectively). Has no activity on postsynaptic mGlu receptors or ionotropic glutamate receptors on neonatal rat motoneurones.

Technical Data

M. Wt 275.2
Storage Store at RT
CAS Number 170984-70-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 275.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.17 mL 36.34 mL
5 mM 0.73 mL 3.63 mL 7.27 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

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Product Datasheets

Certificate of Analysis is currently unavailable on-line.
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Safety Datasheet


References are publications that support the products' biological activity.

Thomas et al (1996) α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 35 637 PMID: 8887973

Jane et al (1996) Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon 109-110 313 PMID:

Thomas et al (1995) Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr. 21 P616 PMID:

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Keywords: MSOPPE, supplier, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience

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