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MitoBrilliant™ Live 646 New
Biological Activity for MitoBrilliant™ Live 646
MitoBrilliant probes have been developed to overcome some common limitations encountered with standard mitochondrial trackers, offering clearer answers to scientific questions. They are next-generation fluorescent stains for the localization and tracking of mitochondria in both live and fixed cells. The range harnesses Janelia Fluor® dye technology, conferring some of the properties that make these widely used dyes, into mitochondrial stains.
The MitoBrilliant™ Live dyes accumulate in the mitochondria of live cells in a mitochondrial membrane potential (Δψm) dependent manner. Upon loss of the mitochondrial membrane potential, the dyes disperse, and so provide a dynamic assessment of the mitochondrial membrane potential in live cells. Two dyes are available: MitoBrilliant™ Live 646 (red emission) and MitoBrilliant™ Live 549 (yellow/orange emission).
A universal stain for mitochondria in both live and fixed cells is also available: MitoBrilliant™ 646.
MitoBrilliant is a trademark of Bio-Techne Corp.
|Product Name||Core dye structure||Abs/Em (nm)||Δψm dependent||Live/Fixed cell use||Stain pre-fixed cells?||Image without wash step||Demonstrated Applications|
| MitoBrilliant™ 646 |
Cat. No. 7700
|Janelia Fluor® technology||655/668||No*||Suitable for both live and fixed cell work||Yes||Yes, but replacing media recommended|| Fixed-cell imaging, |
Super-resolution, microscopy – STED,
| MitoBrilliant™ Live 646 |
Cat. No. 7417
|Janelia Fluor® technology||648/662||Yes||Live-cell work only||No||Yes, but replacing media recommended|| Live-cell imaging, |
| MitoBrilliant™ Live 549 |
Cat. No. 7693
|Janelia Fluor® technology||550/568||Yes||Live-cell work only||No||Yes, but replacing media recommended|| Live-cell imaging, |
Optical Data for MitoBrilliant™ Live 646
Technical Data for MitoBrilliant™ Live 646
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for MitoBrilliant™ Live 646
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for MitoBrilliant™ Live 646
The following data is based on the product molecular weight 445.08. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.2 mM||11.23 mL||56.17 mL||112.34 mL|
|1 mM||2.25 mL||11.23 mL||22.47 mL|
|2 mM||1.12 mL||5.62 mL||11.23 mL|
|10 mM||0.22 mL||1.12 mL||2.25 mL|
Product Datasheets for MitoBrilliant™ Live 646
References for MitoBrilliant™ Live 646
References are publications that support the biological activity of the product.
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Citations for MitoBrilliant™ Live 646
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Protocols for MitoBrilliant™ Live 646
The following protocol features additional information for the use of MitoBrilliant™ Live 646 (Cat. No. 7417).
Literature in this Area
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