Miro1 Reducer

Pricing Availability   Qty
Cat.No. 7091 - Miro1 Reducer | C20H16FN7O.HCl
Description: Promotes mitochondrial Rho GTPase 1 (Miro1) degradation
Chemical Name: N-(3-Fluorophenyl)-N'-[4-[[6-(1H-imidazol-1-yl)-4-pyrimidinyl]amino]phenyl]urea hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Promotes proteasomal degradation of Miro1 (mitochondrial Rho GTPase 1). Reduces Miro1 levels in fibroblasts from Parkinson's disease (PD) patients (IC50 = 7.8 μM). Exhibits no significant effect on related outer mitochondrial membrane protein Mitofusin. Reduces stress-induced degeneration of dopaminergic neurons derived from PD patient iPSCs. Rescues age-dependent neuronal loss and prolongs lifespan in fly PD models.

Technical Data

M. Wt 425.85
Formula C20H16FN7O.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
InChI Key UKXRHSHXZHFFTA-UHFFFAOYSA-N
Smiles FC1=CC=CC(NC(NC2=CC=C(C=C2)NC3=CC(N4C=CN=C4)=NC=N3)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.58 100

Preparing Stock Solutions

The following data is based on the product molecular weight 425.85. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.35 mL 11.74 mL 23.48 mL
5 mM 0.47 mL 2.35 mL 4.7 mL
10 mM 0.23 mL 1.17 mL 2.35 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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References

References are publications that support the biological activity of the product.

Hsieh et al (2019) Miro1 marks Parkinson's disease subset and Miro1 reducer rescues reuron ross in Parkinson's models. Cell Metab. 30 1131 PMID: 31564441


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Keywords: Miro1 Reducer, Miro1 Reducer supplier, 1360287-51-9, miro1, proteasomal, degradation, reducer, reduces, mitochondrial, Rho, GTPase, 1, RHOT1, 7091, Tocris Bioscience

Citations for Miro1 Reducer

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