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Description: Highly efficient chemical inducer of proximity (CIP)
Chemical Name: 4-Chloro-N-[2-[3-methoxy-4-(2-propyn-1-yloxy)phenyl]ethyl]-α-(2-propyn-1-yloxy)benzeneacetamide
Purity: ≥98% (HPLC)

Biological Activity for Mandi

Mandi is a chemical inducer of proximity (CIP) in vivo and in vitro (EC50 = 0.43 μM in a luciferase gene expression assay). Mandi induces complex formation between PYR1Mandi, a mutant of Abscisic Acid (Cat. No. 6554) receptor PYR1, and Abscisic Acid insensitive (ABI). Mandi may be used to induce protein colocalization and interaction. It is non-toxic, orthogonal to mammalian processes and other CIPs, and highly cell permeable.

Technical Data for Mandi

M. Wt 411.88
Formula C23H22ClNO4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 374726-62-2
PubChem ID 11292824
Smiles C#CCOC(C=CC(CCNC(C(C1=CC=C(C=C1)Cl)OCC#C)=O)=C2)=C2OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Mandi

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 41.19 100

Preparing Stock Solutions for Mandi

The following data is based on the product molecular weight 411.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.14 mL 24.28 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

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References for Mandi

References are publications that support the biological activity of the product.

Ziegler et al (2022) Mandipropamid as a chemical inducer of proximity for in vivo applications. Nat.Chem.Biol. 18 64 PMID: 34934192

Park et al (2023) An orthogonalized PYR1-based CID module with reprogrammable ligand-binding specificity. Nat.Chem.Biol. PMID: 37872402

If you know of a relevant reference for Mandi, please let us know.

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Citations for Mandi

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