(+)-Abscisic Acid
Biological Activity
Endogenous lanthionine synthetase C-like 2 (LANCL2) ligand. Stimulates glucose uptake by myocytes and pre-adipocytes in vitro, and by brown adipose tissue in vivo. Acts as a pro-inflammatory modulator of innate immune system cells. Stimulates proliferation of human mesenchymal and hematopoietic stem cells. Also used to control Cas9 via a RNA polymerase-based biosensor.
Technical Data
| M. Wt | 264.32 |
| Formula | C15H20O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 21293-29-8 |
| PubChem ID | 5280896 |
| InChI Key | JLIDBLDQVAYHNE-YKALOCIXSA-N |
| Smiles | CC(/C=C/[C@]1(C(C)=CC(CC1(C)C)=O)O)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.43 | 100 | |
| ethanol | 26.43 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.78 mL | 18.92 mL | 37.83 mL |
| 5 mM | 0.76 mL | 3.78 mL | 7.57 mL |
| 10 mM | 0.38 mL | 1.89 mL | 3.78 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.76 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Carbo et al (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-Like 2-based therapeutic for inflammatory bowel disease. J.Med.Chem. 59 10113 PMID: 27933891
Fresia et al (2016) G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2. Sci.Rep. 6 PMID: 27222287
Sturla et al (2017) Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochim.Biophys.Acta. 1862 131 PMID: 27871880
Pu et al (2018) Multidimensional control of Cas9 by evolved RNA polymerase-based biosensors. ACS Chem.Biol. 13 431 PMID: 28809467
If you know of a relevant reference for (+)-Abscisic Acid, please let us know.
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Keywords: (+)-Abscisic Acid, (+)-Abscisic Acid supplier, LANCL2, agonists, ligands, ABA, Abscisic, acid, phytophormone, Other, Synthases/Synthetases, CRISPR, Reagents, 6554, Tocris Bioscience
Citations for (+)-Abscisic Acid
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A collection of over 750 products for cancer research, the guide includes research tools for the study of:
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