Endogenous lanthionine synthetase C-like 2 (LANCL2) ligand. Stimulates glucose uptake by myocytes and pre-adipocytes in vitro, and by brown adipose tissue in vivo. Also acts as a pro-inflammatory modulator of innate immune system cells. Stimulates proliferation of human mesenchymal and hematopoietic stem cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.78 mL||18.92 mL||37.83 mL|
|5 mM||0.76 mL||3.78 mL||7.57 mL|
|10 mM||0.38 mL||1.89 mL||3.78 mL|
|50 mM||0.08 mL||0.38 mL||0.76 mL|
References are publications that support the biological activity of the product.
Carbo et al (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-Like 2-based therapeutic for inflammatory bowel disease. J.Med.Chem. 59 10113 PMID: 27933891
Fresia et al (2016) G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2. Sci.Rep. 6 PMID: 27222287
Sturla et al (2017) Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochim.Biophys.Acta. 1862 131 PMID: 27871880
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Keywords: (+)-Abscisic Acid, (+)-Abscisic Acid supplier, LANCL2, agonists, ligands, ABA, Abscisic, acid, phytophormone, Other, Synthases/Synthetases, 6554, Tocris Bioscience
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