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(+)-Abscisic Acid

Cat. No. 6554 Submit a Review Datasheet / COA / SDS
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Cat.No. 6554 - (+)-Abscisic Acid | C15H20O4 | CAS No. 21293-29-8
Description: Endogenous LANCL2 agonist
Chemical Name: (2Z,4E)-5-[(1S)-1-Hydroxy-2,6,6-trimethyl-4-oxo-2-cyclohexen-1-yl]-3-methyl-2,4-pentadienoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Endogenous lanthionine synthetase C-like 2 (LANCL2) ligand. Stimulates glucose uptake by myocytes and pre-adipocytes in vitro, and by brown adipose tissue in vivo. Acts as a pro-inflammatory modulator of innate immune system cells. Stimulates proliferation of human mesenchymal and hematopoietic stem cells. Also used to control Cas9 via a RNA polymerase-based biosensor.

Technical Data

M. Wt 264.32
Formula C15H20O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 21293-29-8
PubChem ID 5280896
InChI Key JLIDBLDQVAYHNE-YKALOCIXSA-N
Smiles CC(/C=C/[C@]1(C(C)=CC(CC1(C)C)=O)O)=C/C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.43 100
ethanol 26.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 264.32. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.78 mL 18.92 mL 37.83 mL
5 mM 0.76 mL 3.78 mL 7.57 mL
10 mM 0.38 mL 1.89 mL 3.78 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Carbo et al (2016) An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A novel lanthionine synthetase C-Like 2-based therapeutic for inflammatory bowel disease. J.Med.Chem. 59 10113 PMID: 27933891

Fresia et al (2016) G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2. Sci.Rep. 6 PMID: 27222287

Sturla et al (2017) Abscisic acid enhances glucose disposal and induces brown fat activity in adipocytes in vitro and in vivo. Biochim.Biophys.Acta. 1862 131 PMID: 27871880

Pu et al (2018) Multidimensional control of Cas9 by evolved RNA polymerase-based biosensors. ACS Chem.Biol. 13 431 PMID: 28809467

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Keywords: (+)-Abscisic Acid, (+)-Abscisic Acid supplier, LANCL2, agonists, ligands, ABA, Abscisic, acid, phytophormone, Other, Synthases/Synthetases, CRISPR, Reagents, 6554, Tocris Bioscience

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