MAIT 203

Pricing Availability   Qty
Cat.No. 6382 - MAIT 203 | Z-Ala-Gly-Glu-Ala-Cpa-Tyr-Glu-Gly-Gly-Gly-Gly-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-NH2
Description: APC-Asef (RhoGEF4) interaction inhibitor
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibits interaction of APC and Asef (RhoGEF4). Inhibits colorectal cancer cell migration and invasion in vitro.

Technical Data

M. Wt 2517.83
Formula C106H177N43O29
Sequence AGEAXYEGGGGGRKKRRQRRR

(Modifications: Ala-1 = Z-Ala, X-5= 3-Cyclopentyl-L-alanine, Arg-21= C-terminal amide)

Storage Store at -20°C
InChI Key BWXFXXHBUFJJSA-OMOVEONKNA-N
Smiles C[C@H](NC(=O)OCC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1CCCC1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 2 mg/ml in water

References

References are publications that support the biological activity of the product.

Jiang et al (2017) Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat.Chem.Biol. 13 994 PMID: 28759015


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Keywords: MAIT 203, MAIT 203 supplier, MAIT203, APC, Asef, interaction, inhibitors, inhibits, colorectal, cancer, migration, Rho, 6382, Tocris Bioscience

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Literature in this Area

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