L803

Discontinued Product

Unfortunately L803 (Cat. No. 2235) has been withdrawn from sale for commercial reasons.
Cat.No. 2235 - L803 | Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro | CAS No. 348089-28-1
Description: Substrate-competitive inhibitor of GSK-3
Datasheet
Citations
Literature

Biological Activity

Novel phosphopeptide derived from GSK-3 recognition motif that acts as a substrate-competitive inhibitor of GSK-3β (IC50 = 150 μM). Displays minimal inhibition of Cdc2, MAPK, PKA, CK2, PKCδ and PKB at 200 μM.

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP

Technical Data

M. Wt 1198.23
Formula C50H80N13O19P
Sequence KEAPPAPPQSP

(Modifications: Ser-10 = pSer)

Storage Desiccate at -20°C
CAS Number 348089-28-1
PubChem ID 10328948
InChI Key YDKNRHVNWGPNSH-ICYBEGSVSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 1198.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.83 mL 4.17 mL 8.35 mL
5 mM 0.17 mL 0.83 mL 1.67 mL
10 mM 0.08 mL 0.42 mL 0.83 mL
50 mM 0.02 mL 0.08 mL 0.17 mL

Molarity Calculator

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Plotkin et al (2003) Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J.Pharmacol.Exp.Ther. 305 974 PMID: 12626660

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Keywords: L803, supplier, Substrate-competitive, inhibitors, inhibits, GSK-3, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Glycogen, Synthase, Kinase, 3, Glycogen, Synthase, Kinase, Glycogen, Synthase, Kinase, 3, Tocris Bioscience

Citations for L803

Citations are publications that use Tocris products.

Currently there are no citations for L803.

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