L803

Discontinued Product

L803 (Cat. No. 2235) has been withdrawn from sale for commercial reasons.
Cat.No. 2235 - L803 | Lys-Glu-Ala-Pro-Pro-Ala-Pro-Pro-Gln-pSer-Pro | CAS No. 348089-28-1
Description: Substrate-competitive inhibitor of GSK-3
Datasheet
Citations
Reviews
Literature

Biological Activity

Novel phosphopeptide derived from GSK-3 recognition motif that acts as a substrate-competitive inhibitor of GSK-3β (IC50 = 150 μM). Displays minimal inhibition of Cdc2, MAPK, PKA, CK2, PKCδ and PKB at 200 μM.

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP

Technical Data

M. Wt 1198.23
Formula C50H80N13O19P
Sequence KEAPPAPPQSP

(Modifications: Ser-10 = pSer)

Storage Desiccate at -20°C
CAS Number 348089-28-1
PubChem ID 10328948
InChI Key YDKNRHVNWGPNSH-ICYBEGSVSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

References

References are publications that support the biological activity of the product.

Plotkin et al (2003) Insulin mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J.Pharmacol.Exp.Ther. 305 974 PMID: 12626660

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Keywords: L803, L803 supplier, Substrate-competitive, inhibitors, inhibits, GSK-3, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Kinase, 2235, Tocris Bioscience

Citations for L803

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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