L803

Discontinued Product

L803 (Cat. No. 2235) has been withdrawn from sale for commercial reasons.
Description: Substrate-competitive inhibitor of GSK-3
Datasheet
Citations
Reviews
Literature (7)
Pathways (1)

Biological Activity for L803

Novel phosphopeptide derived from GSK-3 recognition motif that acts as a substrate-competitive inhibitor of GSK-3β (IC50 = 150 μM). Displays minimal inhibition of Cdc2, MAPK, PKA, CK2, PKCδ and PKB at 200 μM.

Licensing Information

Sold under licence from Tel Aviv University Future Technology LP

Technical Data for L803

M. Wt 1198.23
Formula C50H80N13O19P
Sequence KEAPPAPPQSP

(Modifications: Ser-10 = pSer)

Storage Desiccate at -20°C
CAS Number 348089-28-1
PubChem ID 10328948
InChI Key YDKNRHVNWGPNSH-ICYBEGSVSA-N
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for L803

References are publications that support the biological activity of the product.

Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J.Pharmacol.Exp.Ther. 305 974 PMID: 12626660

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Keywords: L803, L803 supplier, Substrate-competitive, inhibitors, inhibits, GSK-3, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Kinase, 2235, Tocris Bioscience

Citations for L803

Citations are publications that use Tocris products.

Currently there are no citations for L803.

Reviews for L803

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer Research Product Guide

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Kinases Product Listing

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

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Stem Cells Scientific Review

Stem Cells Scientific Review

Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.

Schizophrenia Poster

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Stem Cells Poster

Stem Cells Poster

Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.

Pathways for L803

Wnt Signaling Pathway

Wnt Signaling Pathway

The Wnt pathway is involved in cellular differentiation and proliferation in adult tissues and also during embryogenesis. Disturbances within the pathway may lead to the formation of tumors and promote metastasis.