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Description: Substrate-competitive inhibitor of GSK-3
Biological Activity for L803
Novel phosphopeptide derived from GSK-3 recognition motif that acts as a substrate-competitive inhibitor of GSK-3β (IC50 = 150 μM). Displays minimal inhibition of Cdc2, MAPK, PKA, CK2, PKCδ and PKB at 200 μM.
Licensing Information
Sold under licence from Tel Aviv University Future Technology LP
Technical Data for L803
| M. Wt | 1198.23 |
| Formula | C50H80N13O19P |
| Sequence |
KEAPPAPPQSP (Modifications: Ser-10 = pSer) |
| Storage | Desiccate at -20°C |
| CAS Number | 348089-28-1 |
| PubChem ID | 10328948 |
| InChI Key | YDKNRHVNWGPNSH-ICYBEGSVSA-N |
| Smiles | [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](COP(O)(O)=O)C(=O)N1CCC[C@H]1C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for L803
References for L803
References are publications that support the biological activity of the product.
Plotkin et al (2003) Ins mimetic action of synthetic phosphorylated peptide inhibitors of glycogen synthase kinase-3. J.Pharmacol.Exp.Ther. 305 974 PMID: 12626660
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Keywords: L803, L803 supplier, Substrate-competitive, inhibitors, inhibits, GSK-3, Glycogen, Synthase, Kinases, 3, Carbohydrate, Metabolism, Kinase, 2235, Tocris Bioscience
Citations for L803
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Currently there are no citations for L803.
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Pathways for L803
