L-Azidonorleucine hydrochloride

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Cat.No. 6585 - L-Azidonorleucine hydrochloride | C6H12N4O2.HCl | CAS No. 1454334-76-9
Description: Unnatural amino acid for bio-orthogonal or fluorescent labeling of newly synthesized proteins
Chemical Name: (S)-2-Amino-6-azidohexanoic acid hydrochloride
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Literature

Biological Activity

Unnatural amino acid; surrogate methionine. Can be incorporated into proteins by a mutant methionyl tRNA synthetase to enable cell-type specific analysis of protein synthesis. For use with bio-orthogonal non-canonical amino-acid tagging (BONCAT) or fluorescent non-canonical amino acid tagging (FUNCAT). Labeling does not affect the normal localization of the labeled proteins.

Technical Data

M. Wt 208.65
Formula C6H12N4O2.HCl
Storage Store at -20°C
CAS Number 1454334-76-9
PubChem ID 121235322
InChI Key RCEAACZNVVRXSJ-JEDNCBNOSA-N
Smiles N[C@H](C(O)=O)CCCCN=[N+]=[N-].Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.86 100

Preparing Stock Solutions

The following data is based on the product molecular weight 208.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.79 mL 23.96 mL 47.93 mL
5 mM 0.96 mL 4.79 mL 9.59 mL
10 mM 0.48 mL 2.4 mL 4.79 mL
50 mM 0.1 mL 0.48 mL 0.96 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Alvarez-Castelao et al (2017) Cell-type-specific metabolic labeling of nascent proteomes in vivo. Nat.Biotechnol. 35 1196 PMID: 29106408

Mahdavi et al (2016) Engineered aminoacyl-tRNA synthetase for cell-selective analysis of mammalian protein synthesis. J.Am.Chem.Soc. 138 4278 PMID: 26991063


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Keywords: L-Azidonorleucine hydrochloride, L-Azidonorleucine hydrochloride supplier, unnatural, amino, acid, UAA, ANL, methionine, surrogate, BONCAT, FUNCAT, bio-orthogonal, fluorescent, non-canonical, tagging, methionyl, tRNA, synthetase, metRS, Biochemicals, and, Molecular, Biology, Unnatural, Amino, Acids, 6585, Tocris Bioscience

Citations for L-Azidonorleucine hydrochloride

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Literature in this Area

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