ITX 3

Pricing Availability Delivery Time Qty
Cat.No. 3792 - ITX 3 | C22H17N3OS | CAS No. 347323-96-0
Description: Selective inhibitor of TrioN RhoGEF activity
Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

Technical Data

M. Wt 371.45
Formula C22H17N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 347323-96-0
PubChem ID 1362865
InChI Key SJMYMKPBODEZSH-DEDYPNTBSA-N
Smiles CC4=C(C=C(C)N4C5=CC=CC=C5)\C=C3/C(N2C1=CC=CC=C1N=C2S3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 1.86 5

Preparing Stock Solutions

The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.69 mL 13.46 mL 26.92 mL
5 mM 0.54 mL 2.69 mL 5.38 mL
10 mM 0.27 mL 1.35 mL 2.69 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657 PMID: 19549603


If you know of a relevant reference for ITX 3, please let us know.

View Related Products by Product Action

View all GTPase Inhibitors

Keywords: ITX3 selective TrioN RhoGEFs guanine nucleotide exchange factors inhibitors inhibits RhoG Rac1 GTPases small G proteins GTPase

Citations for ITX 3

Citations are publications that use Tocris products.

Currently there are no citations for ITX 3. Do you know of a great paper that uses ITX 3 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for ITX 3

Protocols

TODO: Add Protocols