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Cat.No. 3792 - ITX 3 | C22H17N3OS | CAS No. 347323-96-0
Description: Selective TrioN RhoGEF activity inhibitor
Chemical Name: (E)-2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]thiazolo[3,2-a]benzimidazol-3(2H)-one
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.

Technical Data

M. Wt 371.45
Formula C22H17N3OS
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 347323-96-0
PubChem ID 1362865
Smiles CC4=C(C=C(C)N4C5=CC=CC=C5)\C=C3/C(N2C1=CC=CC=C1N=C2S3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 1.86 5

Preparing Stock Solutions

The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 53.84 mL 269.22 mL 538.43 mL
0.25 mM 10.77 mL 53.84 mL 107.69 mL
0.5 mM 5.38 mL 26.92 mL 53.84 mL
2.5 mM 1.08 mL 5.38 mL 10.77 mL

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References are publications that support the biological activity of the product.

Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657 PMID: 19549603

If you know of a relevant reference for ITX 3, please let us know.

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Keywords: ITX 3, ITX 3 supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, inhibits, RhoG, Rac1, GTPases, small, G, proteins, Rho, 3792, Tocris Bioscience

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