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Selective inhibitor of TrioN RhoGEF activity. Inhibits TrioN-mediated GTP exchange on RhoG and Rac1, formation of TrioN-induced cellular structures in REF52 fibroblasts and NGF-mediated neurite outgrowth in PC12 cells in vitro.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 371.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||53.84 mL||269.22 mL||538.43 mL|
|0.25 mM||10.77 mL||53.84 mL||107.69 mL|
|0.5 mM||5.38 mL||26.92 mL||53.84 mL|
|2.5 mM||1.08 mL||5.38 mL||10.77 mL|
References are publications that support the biological activity of the product.
Bouquier et al (2009) A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway. Chem.Biol. 16 657 PMID: 19549603
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Keywords: ITX 3, ITX 3 supplier, ITX3, selective, TrioN, RhoGEFs, guanine, nucleotide, exchange, factors, inhibitors, inhibits, RhoG, Rac1, GTPases, small, G, proteins, Rho, 3792, Tocris Bioscience
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