Isradipine

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Cat.No. 2004 - Isradipine | C19H21N3O5 | CAS No. 75695-93-1
Description: Ca2+ channel blocker (L-type)
Alternative Names: PN 200-110
Chemical Name: 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations (4)
Reviews
Literature

Biological Activity

Potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo, exerting primary effects on vascular tissue with secondary negative chronotropic action.

Compound Libraries

Isradipine is also offered as part of the Tocriscreen Plus and Tocriscreen Library of FDA-Approved Compounds. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 371.39
Formula C19H21N3O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 75695-93-1
PubChem ID 3784
InChI Key HMJIYCCIJYRONP-UHFFFAOYSA-N
Smiles COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.57 50
ethanol 7.43 20

Preparing Stock Solutions

The following data is based on the product molecular weight 371.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.39 mL 26.93 mL 53.85 mL
2.5 mM 1.08 mL 5.39 mL 10.77 mL
5 mM 0.54 mL 2.69 mL 5.39 mL
25 mM 0.11 mL 0.54 mL 1.08 mL

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References

References are publications that support the biological activity of the product.

Hof et al (1984) PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J.Cardiovasc.Pharmacol. 6 399 PMID: 6202964

Wada et al (1985) Separation of the coronary vasodilator from the cardiac effects of PN 200-110, a new dihydropyridine calcium antagonist, in the dog heart. J.Cardiovasc.Pharmacol. 7 190 PMID: 2580142

Ruegg and Hof (1990) Pharmacology of the calcium antagonist isradipine. Drugs 40 3


If you know of a relevant reference for Isradipine, please let us know.

View Related Products by Product Action

View all Voltage-gated Calcium Channel (CaV) Blockers

Keywords: Isradipine, Isradipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, voltage-gated, voltage-dependent, PN200110, PN, 200-110, Voltage-gated, 2004, Tocris Bioscience

4 Citations for Isradipine

Citations are publications that use Tocris products. Selected citations for Isradipine include:

Pourbadie et al (2015) Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. J Neurosci 10 e0117555 PMID: 25689857

Saszik and DeVries (2012) A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light. J Neurosci 32 297 PMID: 22219291

Dragicevic et al (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. PLoS One 137 2287 PMID: 24934288

Murray et al (2011) Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol 106 925 PMID: 21653728


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Literature in this Area

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