Ischemin sodium salt

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Cat.No. 4695 - Ischemin sodium salt | C15H16N3O4SNa
Description: CBP inhibitor; cell permeable
Chemical Name: 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

CBP bromodomain inhibitor. Inhibits p53 interaction with CBP and decreases p53 transcriptional activity. Protects against Doxorubicin-induced apoptosis in cardiomyocytes in vitro. Cell permeable.

Technical Data

M. Wt 357.36
Formula C15H16N3O4SNa
Storage Store at +4°C
Purity ≥99% (HPLC)
PubChem ID 64983
InChI Key XWNMORIHKRROGW-UHFFFAOYSA-N
Smiles CC1=CC(/N=N/C2=C(C)C=C(C)C(S(=O)(O[Na])=O)=C2)=C(N)C=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.74 100
DMSO 35.74 100

Preparing Stock Solutions

The following data is based on the product molecular weight 357.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.8 mL 13.99 mL 27.98 mL
5 mM 0.56 mL 2.8 mL 5.6 mL
10 mM 0.28 mL 1.4 mL 2.8 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Borah et al (2011) A small molecule binding to the coactivator CREB-binding protein blocks apoptosis in cardiomyocytes. Chem.Biol. 18 531 PMID: 21513889


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Keywords: Ischemin sodium salt, supplier, CBP, bromodomain, inhibitors, inhibits, p53, interaction, cell, permeable, 1357059, 00, 7, Bromodomains, Bromodomains, Tocris Bioscience

Citations for Ischemin sodium salt

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.