IQ 1S

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Cat.No. 5575 - IQ 1S | C15H8N3NaO | CAS No. 1421610-21-0
Description: JNK inhibitor; anti-inflammatory; also NO donor
Chemical Name: 11H-Indeno[1,2-b]quinoxalin-11-one oxime sodium salt
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

JNK inhibitor (Kd values are 87, 360 and 390 nM for JNK3, JNK2 and JNK1, respectively). Inhibits LPS-induced proinflammatory cytokine and nitric oxide production in vitro. Attenuates collagen-induced arthritis severity and inhibits murine delayed-type hypersensitivity in vivo. Anti-inflammatory and immunosuppressive. Also releases NO upon metabolism by liver microsomes.

Technical Data

M. Wt 269.23
Formula C15H8N3NaO
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 1421610-21-0
PubChem ID 72193876
InChI Key JBNHEGDICQSOLR-NYAKATHWSA-M
Smiles [Na]O/N=C1C2=NC3=CC=CC=C3N=C2C4=C\1C=CC=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 5.38 20 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 269.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 18.57 mL 92.86 mL 185.71 mL
1 mM 3.71 mL 18.57 mL 37.14 mL
2 mM 1.86 mL 9.29 mL 18.57 mL
10 mM 0.37 mL 1.86 mL 3.71 mL

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References

References are publications that support the biological activity of the product.

Schepetkin et al (2015) Anti-Inflammatory effects and joint protection in collagen-induced arthritis after treatment with IQ-1S, a selective c-Jun N-terminal kinase Inhibitor. J.Pharmacol.Exp.Ther. 353 505 PMID: 25784649

Schepetkin et al (2012) Identification and characterization of a novel class of c-Jun N-terminal kinase inhibitors. Mol.Pharmacol. 81 832 PMID: 22434859

Atochin et al (2016) A novel dual NO-donating oxime and c-Jun N-terminal kinase inhibitor protects against cerebral ischemia-reperfusion injury in mice. Neurosci.Lett. 618 45 PMID: 26923672


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Keywords: IQ 1S, IQ 1S supplier, IQ1S, JNK, inhibitors, inhibits, anti-inflammatory, immunosuppresents, NO, donor, JNK/c-jun, ROS, Donors, 5575, Tocris Bioscience

Citations for IQ 1S

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

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MAPK Signaling

MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

Pathways for IQ 1S

MAPK

MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.