Honokiol

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Cat.No. 4590 - Honokiol | C18H18O2 | CAS No. 35354-74-6
Description: Blocks NF-κB activation; also anti-inflammatory and antioxidant
Chemical Name: 5,3'-Diallyl-2,4'-dihydroxybiphenyl
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature
Pathways

Biological Activity

Anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

Technical Data

M. Wt 266.33
Formula C18H18O2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 35354-74-6
PubChem ID 72303
InChI Key FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.63 100
ethanol 26.63 100

Preparing Stock Solutions

The following data is based on the product molecular weight 266.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.75 mL 18.77 mL 37.55 mL
5 mM 0.75 mL 3.75 mL 7.51 mL
10 mM 0.38 mL 1.88 mL 3.75 mL
50 mM 0.08 mL 0.38 mL 0.75 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951

Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545


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Keywords: Honokiol, supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Tocris Bioscience

Citations for Honokiol

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Literature in this Area

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Pathways for Honokiol

NF-κB

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.

Protocols

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