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Biological Activity for Hemopressin (rat)
Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
Technical Data for Hemopressin (rat)
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Hemopressin (rat)
|Solubility||Soluble to 2 mg/ml in 20% acetonitrile|
Product Datasheets for Hemopressin (rat)
References for Hemopressin (rat)
References are publications that support the biological activity of the product.
Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 104 20588 PMID: 18077343
Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972
Todd et al (2010) The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 30 7369 PMID: 20505104
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Keywords: Hemopressin (rat), Hemopressin (rat) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, /, Activators, Other, Receptors, 1764, Tocris Bioscience
Citations for Hemopressin (rat)
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.