H3K4(Me) (1-20)

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Cat.No. 6214 - H3K4(Me) (1-20) | Ala-Arg-Thr-Lys(Me)-Gln-Thr-Ala-Arg-Lys-Ser-Thr-Gly-Gly-Lys-Ala-Pro-Arg-Lys-Gln-Leu
Description: Histone H3 peptide; substrate for methyltransferase/demethylase enzymes
Datasheet
Citations
Reviews
Literature

Biological Activity

Histone peptide. Substrate for methyltransferase/demethylase enzymes. Peptide derived from human histone isotype 3.1.

Technical Data

M. Wt 2197.57
Formula C92H169N35O27
Sequence ARTKQTARKSTGGKAPRKQL

(Modifications: Lys-4 = Lys(Me))

Storage Store at -20°C
PubChem ID 127021048
InChI Key OTYQVHDKBVNJKN-QWAUVACXNA-N
Smiles [H]N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCNC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 2197.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.46 mL 2.28 mL 4.55 mL
5 mM 0.09 mL 0.46 mL 0.91 mL
10 mM 0.05 mL 0.23 mL 0.46 mL
50 mM 0.01 mL 0.05 mL 0.09 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Mulder et al (2017) Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Res. 35 2428 PMID: 17392337


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Keywords: H3K4(Me) (1-20), supplier, histone, H3, peptide, demethylases, demethylation, methyltransferases, methylation, enzyme, substrate, Histone, Peptides, Enzyme, Substrates, /, Activators, Enzyme, Substrates, /, Activators, Tocris Bioscience

Citations for H3K4(Me) (1-20)

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Literature in this Area

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