Histone Peptides

Histones are the core components of the nucleosome, the building block of eukaryotic chromatin. Post-translational modifications on the histone N-termini are involved in regulating gene transcription. Histone peptides can be used as substrates for histone methyltransferase/demethylase enzymes.

Products
Literature

Substrates

Cat No Product Name / Activity
6211 H3K27(Me) (15-34)
Histone H3 peptide
6212 H3K27(Me2) (15-34)
Histone H3 peptide
6213 H3K27(Me3) (15-34)
Histone H3 peptide
6214 H3K4(Me) (1-20)
Histone H3 peptide
6215 H3K4(Me2) (1-20)
Histone H3 peptide
6216 H3K4(Me3) (1-20)
Histone H3 peptide
6217 Histone H3 (1-34)
Histone H3 peptide

Related Targets

    Literature for Histone Peptides

    Tocris offers the following scientific literature for Histone Peptides to showcase our products. We invite you to request* or download your copy today!

    *Please note that Tocris will only send literature to established scientific business / institute addresses.


    Cancer

    Cancer Research Product Guide

    A collection of over 750 products for cancer research, the guide includes research tools for the study of:

    • Cancer Metabolism
    • Epigenetics in Cancer
    • Receptor Signaling
    • Cell Cycle and DNA Damage Repair
    • Angiogenesis
    • Invasion and Metastasis
    Epigenetics

    Epigenetics Scientific Review

    Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

    Epigenetics

    Epigenetics Research Bulletin

    Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

    • Bromodomains
    • DNA Methyltransferases
    • Histone Deacetylases
    • Histone Demethylases
    • Histone Methyltransferases
    Epigenetics in Cancer

    Epigenetics in Cancer Poster

    Adapted from the 2015 Cancer Product Guide Edition 3, this poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.

    Rheumatoid Arthritis

    Rheumatoid Arthritis Poster

    Rheumatoid arthritis (RA) is a chronic destructive inflammatory autoimmune disease that results from a breakdown in immune tolerance, for reasons that are as yet unknown. This poster summarizes the pathology of RA and the inflammatory processes involved, as well as describing some of the epigenetic modifications associated with the disease and the potential for targeting these changes in the discovery of new treatments.