H3K27(Me3) (15-34)
Biological Activity
Histone peptide. Substrate for methyltransferase/demethylase enzymes. Peptide derived from human histone isotype 3.1.
Technical Data
| M. Wt | 2023.38 |
| Formula | C87H157N30O25 |
| Sequence |
APRKQLATKAARKSAPATGG (Modifications: Lys-13 = Lys(Me3)) |
| Storage | Store at -20°C |
| InChI Key | SYQRIXOTDLKCAB-UWJSCCMBNA-N |
| Smiles | [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCC[N](C)(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 2023.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.49 mL | 2.47 mL | 4.94 mL |
| 5 mM | 0.1 mL | 0.49 mL | 0.99 mL |
| 10 mM | 0.05 mL | 0.25 mL | 0.49 mL |
| 50 mM | 0.01 mL | 0.05 mL | 0.1 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chadwick and Willard et al (2004) Multiple spatially distinct types of facultative heterochromatin on the human inactive X chromosome. Proc.Natl.Acad.Sci.U.S.A. 101 17450 PMID: 15574503
If you know of a relevant reference for H3K27(Me3) (15-34), please let us know.
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Keywords: H3K27(Me3) (15-34), supplier, histone, H3, peptide, demethylases, demethylation, methyltransferases, methylation, enzyme, substrate, Histone, Peptides, Enzyme, Substrates, /, Activators, Enzyme, Substrates, /, Activators, Tocris Bioscience
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