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Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 284.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||7.03 mL||35.17 mL||70.35 mL|
|2.5 mM||1.41 mL||7.03 mL||14.07 mL|
|5 mM||0.7 mL||3.52 mL||7.03 mL|
|25 mM||0.14 mL||0.7 mL||1.41 mL|
References are publications that support the biological activity of the product.
Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157
If you know of a relevant reference for Golgicide A, please let us know.
Keywords: Golgicide A, Golgicide A supplier, potent, specific, reversible, inhibitors, inhibits, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange, Arf, Translocation, 3584, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for Golgicide A include:
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034
Gomes-da-Silva et al (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ 26 1467 PMID: 30349077
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