Golgicide A

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Cat.No. 3584 - Golgicide A | C17H14F2N2 | CAS No. 1139889-93-2
Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF
Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Compound Libraries

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Technical Data

M. Wt 284.3
Formula C17H14F2N2
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1139889-93-2
PubChem ID 25113626
InChI Key NJZHEQOUHLZCOX-FTLRAWMYSA-N
Smiles FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.21 50

Preparing Stock Solutions

The following data is based on the product molecular weight 284.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 7.03 mL 35.17 mL 70.35 mL
2.5 mM 1.41 mL 7.03 mL 14.07 mL
5 mM 0.7 mL 3.52 mL 7.03 mL
25 mM 0.14 mL 0.7 mL 1.41 mL

Molarity Calculator

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References

References are publications that support the biological activity of the product.

Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157


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View all Arf GTPase Inhibitors

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1 Citation for Golgicide A

Citations are publications that use Tocris products. Selected citations for Golgicide A include:

Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034


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Literature in this Area

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